Antiatherogenic changes in the lipid spectrum of blood serum under various conditions, such as mountain and climate therapy in Caucasian resorts at moderate altitudes, interval hypobaric therapy, and trekking at moderate altitude, combined with the regular application of cold and the performance of special exercises increasing cold resistance, based on Tibetan gTum-mo Yoga, have been studied. Using an exponential model, the rates of changes in the total cholesterol, cholesterol of high- and low-density lipoproteins (HDL and LDL, respectively), very low-density lipoproteins (VLDL), and triglycerides in blood serum were compared. Application of a new calculation algorithm allowed demonstrating a higher rate of antiatherogenic changes in the lipid spectrum of the blood, such as a decrease in total cholesterol and LDL and an increase in HDL contents after the use of a combination of altitude hypoxia, moderate physical training, and special exercises to raise resistance to cold temperatures (Tibetan gTum-mo Yoga).