We compare enhancements of mesospheric volume mixing ratios of hydroperoxyl radical (Formula presented.) and nitric acid (Formula presented.), as well as ozone depletion in the Northern Hemisphere (NH) polar night regions during energetic particle precipitation (EPP) in January of 2005 and 2012. We utilize mesospheric observations of (Formula presented.), (Formula presented.), and ozone from the Microwave Limb Sounder (MLS/Aura). During the second half of January 2005 and 2012, the GOES satellite identified strong solar proton events with virtually the same proton flux parameters. Geomagnetic disturbances in January of 2005 were stronger, with Dst decreasing up to 100 nT compared to January 2012 while the Dst drop did not exceed 70 nT. Comparison of observations made with the MLS/Aura shows the highest change of (Formula presented.) and (Formula presented.) concentrations and also the deepest ozone destruction at the latitudinal range from (Formula presented.) NH to (Formula presented.) NH inside the north polar vortex right after the spike in energetic particle flux registered by GOES satellites. MLS/Aura observations show (Formula presented.) maximum enhancements of about 1.90 ppb and 1.66 ppb around 0.5 hPa (about 55 km) in January 2005 and January 2012, respectively. The (Formula presented.) increases lead to short-term ozone destruction in the mesosphere, which is seen in MLS/Aura ozone data. The maximum (Formula presented.) enhancement is about 1.05 ppb and 1.62 ppb around 0.046 hPa (about 70 km) after the onset of EPP in the second half of January 2005 and January 2012, respectively. Ozone maximum depletion is observed around 0.02 hPa (about 75 km). Ozone recovery after EPP was much faster in January 2005 than in January 2012.