Comparative scintigraphic study of 99mTc ciprofloxacin pharmacokinetics after intravenous and lymphotropic administration in experimental pulmonary suppuration. / Lishmanov, Yu B.; Sazonova, S. I.; Sokolovich, E. G.; Chernov, V. I.
In: Bulletin of Experimental Biology and Medicine, Vol. 139, No. 1, 01.01.2005, p. 94-97.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Comparative scintigraphic study of 99mTc ciprofloxacin pharmacokinetics after intravenous and lymphotropic administration in experimental pulmonary suppuration
AU - Lishmanov, Yu B.
AU - Sazonova, S. I.
AU - Sokolovich, E. G.
AU - Chernov, V. I.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Intravenously injected 99mTc ciprofloxacin is rapidly accumulated and washed from the septic focus. Lymphotropic injections provide targeted and long-lasting effect of the antibiotic. After injection into the interspinous ligament the drug slowly enters the inflammation area (by-passing the urinary organs and liver), where it is maximally accumulated only after 24 h, which allows to reduce the number of injections and the total dose of the antibiotic.
AB - Intravenously injected 99mTc ciprofloxacin is rapidly accumulated and washed from the septic focus. Lymphotropic injections provide targeted and long-lasting effect of the antibiotic. After injection into the interspinous ligament the drug slowly enters the inflammation area (by-passing the urinary organs and liver), where it is maximally accumulated only after 24 h, which allows to reduce the number of injections and the total dose of the antibiotic.
KW - Tc ciprofloxacin
KW - Intravenous injections
KW - Lymphotropic injections
UR - http://www.scopus.com/inward/record.url?scp=19444373391&partnerID=8YFLogxK
U2 - 10.1007/s10517-005-0223-4
DO - 10.1007/s10517-005-0223-4
M3 - Article
C2 - 16142288
AN - SCOPUS:19444373391
VL - 139
SP - 94
EP - 97
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 1
ER -
ID: 45772549