Combined diagnostics of lung cancer using exhaled breath analsysis and sputum cytology. / Arseniev, A. I.; Nefedova, A. V.; Ganeev, A. A.; Nefedov, A. O.; Novikov, S. N.; Barchuk, A. A.; Kanaev, S. V.; Jahatspanian, I. E.; Gubal, A. R.; Kononov, A. S.; Tarkov, S. A.; Aristidov, N. Y.
In: Voprosy Onkologii, Vol. 66, No. 4, 01.01.2020, p. 381-384.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Combined diagnostics of lung cancer using exhaled breath analsysis and sputum cytology
AU - Arseniev, A. I.
AU - Nefedova, A. V.
AU - Ganeev, A. A.
AU - Nefedov, A. O.
AU - Novikov, S. N.
AU - Barchuk, A. A.
AU - Kanaev, S. V.
AU - Jahatspanian, I. E.
AU - Gubal, A. R.
AU - Kononov, A. S.
AU - Tarkov, S. A.
AU - Aristidov, N. Y.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - In this article we summarize our own experience of lung cancer diagnostics using exhaled breath analysis with a nonselective method using metal oxide chernoresistor gas sensors with cross-sensitivity combined with the sputum cytology. Volatile organic compounds of exhaled breath change the conductivity of the sensor, the resulting pulse is displayed as a peak on the graph, the area of which is used as test results. The combination of two diagnostic techniques in 204 participants demonstrated the possibility of non-invasively detecting the disease at an early stage. The sensitivity, specificity and accuracy of the breath analysis was 91.2%, 100% and 93.4%, respectively. The combination of the breath test and the sputum cytology compared to the breath test alone showed statistically significant (p = 0.03) increase in sensitivity to 96.8% (95% CI: 80.9%-99%) with acceptable decrease in specificity to 93.4% (95% CI: 88%-96%). The convenience of analysis and realtime measurements show some promise for the early detection.
AB - In this article we summarize our own experience of lung cancer diagnostics using exhaled breath analysis with a nonselective method using metal oxide chernoresistor gas sensors with cross-sensitivity combined with the sputum cytology. Volatile organic compounds of exhaled breath change the conductivity of the sensor, the resulting pulse is displayed as a peak on the graph, the area of which is used as test results. The combination of two diagnostic techniques in 204 participants demonstrated the possibility of non-invasively detecting the disease at an early stage. The sensitivity, specificity and accuracy of the breath analysis was 91.2%, 100% and 93.4%, respectively. The combination of the breath test and the sputum cytology compared to the breath test alone showed statistically significant (p = 0.03) increase in sensitivity to 96.8% (95% CI: 80.9%-99%) with acceptable decrease in specificity to 93.4% (95% CI: 88%-96%). The convenience of analysis and realtime measurements show some promise for the early detection.
KW - Exhaled breath
KW - Gas analyzer
KW - Lung cancer
KW - Screening
KW - Sputum cytology
UR - http://www.scopus.com/inward/record.url?scp=85098263530&partnerID=8YFLogxK
U2 - 10.37469/0507-3758-2020-66-4-381-384
DO - 10.37469/0507-3758-2020-66-4-381-384
M3 - Article
AN - SCOPUS:85098263530
VL - 66
SP - 381
EP - 384
JO - Вопросы онкологии
JF - Вопросы онкологии
SN - 0507-3758
IS - 4
ER -
ID: 102222226