Chronic Sarcoidosis: Diagnostic Difficulties and Search for New Criteria of Inflammatory Activity (A Case Report and Literature Review)

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Chronic Sarcoidosis: Diagnostic Difficulties and Search for New Criteria of Inflammatory Activity (A Case Report and Literature Review). / Starshinova, A.; Berg, E.; Rubinstein, A.; Kulpina, A.; Kudriavtsev, I.; Kudlay, D.

In: Journal of Clinical Medicine, Vol. 13, No. 22, 2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{d8255a09ec3b42738486e74ed281f321,

title = "Chronic Sarcoidosis: Diagnostic Difficulties and Search for New Criteria of Inflammatory Activity (A Case Report and Literature Review)",

abstract = "Sarcoidosis is a systemic inflammatory disease with an unknown etiology and a wide range of clinical manifestations. The incidence of sarcoidosis ranges from approximately 1 to 15 cases per 100,000 individuals per year worldwide. The significant variability in clinical presentations and target organs, as well as concomitant diseases, greatly complicates diagnosis. We analyzed articles in PubMed, Scopus, Cochrane Library, and Embase, where databases were searched using the keywords “chronic sarcoidosis”, “diagnosis of sarcoidosis”, “course of sarcoidosis”, “pulmonary sarcoidosis”, “cardiac sarcoidosis”, “skin sarcoidosis”, “neurosarcoidosis”, “ocular sarcoidosis”, and “autoimmune inflammation”. Studies on the course and diagnosis of sarcoidosis with a deep search of ten years were included. In this review, we present an analysis of publications on the course and diagnosis of chronic sarcoidosis, as well as a clinical case. We have noted that the diagnosis of chronic sarcoidosis is particularly difficult due to the lack of specific biomarkers or their combination. The development and introduction of new diagnostic criteria for this disease will contribute to increasing the level of efficiency, not only of the diagnostic complex, but also the prognosis of the development and course of the pathological process. Conclusion: For the most accurate diagnosis and determination of prognosis, the existence of a single immunological or imaging marker with sufficient sensitivity and specificity is necessary. {\textcopyright} 2024 Elsevier B.V., All rights reserved.",

keywords = "autoimmune inflammation, biomarkers, cardiac sarcoidosis, chronic sarcoidosis, diagnosis of sarcoidosis, neurosarcoidosis, ocular sarcoidosis, pulmonary sarcoidosis, skin sarcoidosis, leflunomide, prednisolone, abdominal radiography, adult, anamnesis, B lymphocyte, body plethysmography, case report, chronic disease, clinical article, coughing, drug dose reduction, dyspnea, echography, fiberoptic bronchoscopy, hemoptysis, hepatosplenomegaly, histopathology, human, human tissue, lung biopsy, lung sarcoidosis, natural killer T cell, plasmapheresis, regulatory T lymphocyte, Review, sputum, walking difficulty, weakness",

author = "A. Starshinova and E. Berg and A. Rubinstein and A. Kulpina and I. Kudriavtsev and D. Kudlay",

note = "Export Date: 01 November 2025; Cited By: 2; Correspondence Address: A. Starshinova; Department of Mathematics and Computer Science, St. Petersburg State University, St. Petersburg, 199034, Russian Federation; email: asya.starshinova@mail.ru",

year = "2024",

doi = "10.3390/jcm13226974",

language = "Английский",

volume = "13",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "MDPI AG",

number = "22",

}

RIS

TY - JOUR

T1 - Chronic Sarcoidosis: Diagnostic Difficulties and Search for New Criteria of Inflammatory Activity (A Case Report and Literature Review)

AU - Starshinova, A.

AU - Berg, E.

AU - Rubinstein, A.

AU - Kulpina, A.

AU - Kudriavtsev, I.

AU - Kudlay, D.

N1 - Export Date: 01 November 2025; Cited By: 2; Correspondence Address: A. Starshinova; Department of Mathematics and Computer Science, St. Petersburg State University, St. Petersburg, 199034, Russian Federation; email: asya.starshinova@mail.ru

PY - 2024

Y1 - 2024

N2 - Sarcoidosis is a systemic inflammatory disease with an unknown etiology and a wide range of clinical manifestations. The incidence of sarcoidosis ranges from approximately 1 to 15 cases per 100,000 individuals per year worldwide. The significant variability in clinical presentations and target organs, as well as concomitant diseases, greatly complicates diagnosis. We analyzed articles in PubMed, Scopus, Cochrane Library, and Embase, where databases were searched using the keywords “chronic sarcoidosis”, “diagnosis of sarcoidosis”, “course of sarcoidosis”, “pulmonary sarcoidosis”, “cardiac sarcoidosis”, “skin sarcoidosis”, “neurosarcoidosis”, “ocular sarcoidosis”, and “autoimmune inflammation”. Studies on the course and diagnosis of sarcoidosis with a deep search of ten years were included. In this review, we present an analysis of publications on the course and diagnosis of chronic sarcoidosis, as well as a clinical case. We have noted that the diagnosis of chronic sarcoidosis is particularly difficult due to the lack of specific biomarkers or their combination. The development and introduction of new diagnostic criteria for this disease will contribute to increasing the level of efficiency, not only of the diagnostic complex, but also the prognosis of the development and course of the pathological process. Conclusion: For the most accurate diagnosis and determination of prognosis, the existence of a single immunological or imaging marker with sufficient sensitivity and specificity is necessary. © 2024 Elsevier B.V., All rights reserved.

AB - Sarcoidosis is a systemic inflammatory disease with an unknown etiology and a wide range of clinical manifestations. The incidence of sarcoidosis ranges from approximately 1 to 15 cases per 100,000 individuals per year worldwide. The significant variability in clinical presentations and target organs, as well as concomitant diseases, greatly complicates diagnosis. We analyzed articles in PubMed, Scopus, Cochrane Library, and Embase, where databases were searched using the keywords “chronic sarcoidosis”, “diagnosis of sarcoidosis”, “course of sarcoidosis”, “pulmonary sarcoidosis”, “cardiac sarcoidosis”, “skin sarcoidosis”, “neurosarcoidosis”, “ocular sarcoidosis”, and “autoimmune inflammation”. Studies on the course and diagnosis of sarcoidosis with a deep search of ten years were included. In this review, we present an analysis of publications on the course and diagnosis of chronic sarcoidosis, as well as a clinical case. We have noted that the diagnosis of chronic sarcoidosis is particularly difficult due to the lack of specific biomarkers or their combination. The development and introduction of new diagnostic criteria for this disease will contribute to increasing the level of efficiency, not only of the diagnostic complex, but also the prognosis of the development and course of the pathological process. Conclusion: For the most accurate diagnosis and determination of prognosis, the existence of a single immunological or imaging marker with sufficient sensitivity and specificity is necessary. © 2024 Elsevier B.V., All rights reserved.

KW - autoimmune inflammation

KW - biomarkers

KW - cardiac sarcoidosis

KW - chronic sarcoidosis

KW - diagnosis of sarcoidosis

KW - neurosarcoidosis

KW - ocular sarcoidosis

KW - pulmonary sarcoidosis

KW - skin sarcoidosis

KW - leflunomide

KW - prednisolone

KW - abdominal radiography

KW - adult

KW - anamnesis

KW - B lymphocyte

KW - body plethysmography

KW - case report

KW - chronic disease

KW - clinical article

KW - coughing

KW - drug dose reduction

KW - dyspnea

KW - echography

KW - fiberoptic bronchoscopy

KW - hemoptysis

KW - hepatosplenomegaly

KW - histopathology

KW - human

KW - human tissue

KW - lung biopsy

KW - lung sarcoidosis

KW - natural killer T cell

KW - plasmapheresis

KW - regulatory T lymphocyte

KW - Review

KW - sputum

KW - walking difficulty

KW - weakness

U2 - 10.3390/jcm13226974

DO - 10.3390/jcm13226974

M3 - статья

VL - 13

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 22

ER -

ID: 143413750