Characteristics of memantine influences on learning in the morris water maze

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Characteristics of memantine influences on learning in the morris water maze. / Murovets, V. O.; Aleksandrov, A. A.

In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 70, No. 1, 2020, p. 50-61.

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Murovets, V. O. ; Aleksandrov, A. A. / Characteristics of memantine influences on learning in the morris water maze. In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2020 ; Vol. 70, No. 1. pp. 50-61.

BibTeX

@article{e837b4aa18d443c6b079dc4521b52bf8,

title = "Characteristics of memantine influences on learning in the morris water maze",

abstract = "Effects of memantine on the spatial learning of rats were investigated using standard Morris water maze to elucidate elements of learning depending on the NMDA receptor system. Intraperitoneally applied memantine (20 mg/kg) totally abolished task acquisition. In addition, a suppression of noneffective non-spatial search strategies was impaired, that could be concluded from increases of thigmotaxis and leavings of a platform. However, a drug-free non-spatial pretraining during which the animals acquired procedural elements of the task ameliorated the memantine-induced spatial learning impairment. In memantine group with pretraining, occurrences of thigmotaxis and leavings of a platform were reduced. The obtained data suggest that the spatial learning in the Morris water maze is relatively independent of hippocampal NMDA receptors and NMDA receptor antagonists have negative effects on the acquisition of new behavioral skills and/or the suppression of ineffective strategy of behavior.",

keywords = "Cognitive disturbances, Memantine, Morris water maze task, NMDA receptor, Spatial learning and memory",

author = "Murovets, {V. O.} and Aleksandrov, {A. A.}",

year = "2020",

doi = "10.31857/S0044467720010104",

language = "русский",

volume = "70",

pages = "50--61",

journal = "ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА",

issn = "0044-4677",

publisher = "Издательство {"}Наука{"}",

number = "1",

}

RIS

TY - JOUR

T1 - Characteristics of memantine influences on learning in the morris water maze

AU - Murovets, V. O.

AU - Aleksandrov, A. A.

PY - 2020

Y1 - 2020

N2 - Effects of memantine on the spatial learning of rats were investigated using standard Morris water maze to elucidate elements of learning depending on the NMDA receptor system. Intraperitoneally applied memantine (20 mg/kg) totally abolished task acquisition. In addition, a suppression of noneffective non-spatial search strategies was impaired, that could be concluded from increases of thigmotaxis and leavings of a platform. However, a drug-free non-spatial pretraining during which the animals acquired procedural elements of the task ameliorated the memantine-induced spatial learning impairment. In memantine group with pretraining, occurrences of thigmotaxis and leavings of a platform were reduced. The obtained data suggest that the spatial learning in the Morris water maze is relatively independent of hippocampal NMDA receptors and NMDA receptor antagonists have negative effects on the acquisition of new behavioral skills and/or the suppression of ineffective strategy of behavior.

AB - Effects of memantine on the spatial learning of rats were investigated using standard Morris water maze to elucidate elements of learning depending on the NMDA receptor system. Intraperitoneally applied memantine (20 mg/kg) totally abolished task acquisition. In addition, a suppression of noneffective non-spatial search strategies was impaired, that could be concluded from increases of thigmotaxis and leavings of a platform. However, a drug-free non-spatial pretraining during which the animals acquired procedural elements of the task ameliorated the memantine-induced spatial learning impairment. In memantine group with pretraining, occurrences of thigmotaxis and leavings of a platform were reduced. The obtained data suggest that the spatial learning in the Morris water maze is relatively independent of hippocampal NMDA receptors and NMDA receptor antagonists have negative effects on the acquisition of new behavioral skills and/or the suppression of ineffective strategy of behavior.

KW - Cognitive disturbances

KW - Memantine

KW - Morris water maze task

KW - NMDA receptor

KW - Spatial learning and memory

UR - http://www.scopus.com/inward/record.url?scp=85094906103&partnerID=8YFLogxK

U2 - 10.31857/S0044467720010104

DO - 10.31857/S0044467720010104

M3 - статья

AN - SCOPUS:85094906103

VL - 70

SP - 50

EP - 61

JO - ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА

JF - ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА

SN - 0044-4677

IS - 1

ER -

ID: 73212069