TY - JOUR

T1 - Characteristics of Human Cortical Pyramidal Neuron Development during the Second Gestational Trimester

AU - Krasnoshchekova, E. I.

AU - Zykin, P. A.

AU - Tkachenko, L. A.

AU - Smolina, T. Yu.

PY - 2010

Y1 - 2010

N2 - Abstract—Prenatal ontogeny of the human neocortex exhibits specific characteristics that make its organization unique. Therefore, experimental data obtained on animal models cannot be extrapolated to human cortex morphogenesis during the middle and late gestational periods. Characteristics of the development of cortical pyramidal neurons of the human brain were studied in the brains of eight fetuses at gestational ages between 16 and 26 weeks. Immunohistochemical labeling of neurons was performed using antibodies against microtubule associated protein 2 (MAP2), a structural protein of microtubules. Expression of this protein marks the beginning of dendrogenesis. MAP2 is mainly located in the neuron body and dendrites, which allowed the neuron morphotype and location in specific cortical layers to be determined. It was shown that MAP2-immunopositive neurons were identifiable in embryonic cortical layer eV as early as the 18th gestational week. By the 25th gestational week, two populations of pyramidal neurons

AB - Abstract—Prenatal ontogeny of the human neocortex exhibits specific characteristics that make its organization unique. Therefore, experimental data obtained on animal models cannot be extrapolated to human cortex morphogenesis during the middle and late gestational periods. Characteristics of the development of cortical pyramidal neurons of the human brain were studied in the brains of eight fetuses at gestational ages between 16 and 26 weeks. Immunohistochemical labeling of neurons was performed using antibodies against microtubule associated protein 2 (MAP2), a structural protein of microtubules. Expression of this protein marks the beginning of dendrogenesis. MAP2 is mainly located in the neuron body and dendrites, which allowed the neuron morphotype and location in specific cortical layers to be determined. It was shown that MAP2-immunopositive neurons were identifiable in embryonic cortical layer eV as early as the 18th gestational week. By the 25th gestational week, two populations of pyramidal neurons

KW - neocortex

KW - prenatal ontogeny

KW - immunohistochemistry

KW - structural microtubule protein MAP2

KW - critical period of prenatal development.

U2 - 10.1134/S0362119710040079

DO - 10.1134/S0362119710040079

M3 - Article

VL - 36

SP - 427

EP - 432

JO - Human Physiology

JF - Human Physiology

SN - 0362-1197

IS - 4

ER -