Characteristic Profiles of Biologically Active Substances of Blood Plasma Samples from Patients with Tuberculosis Obtained by HPLC

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Characteristic Profiles of Biologically Active Substances of Blood Plasma Samples from Patients with Tuberculosis Obtained by HPLC. / Solov’eva, S. A. ; Bessonova, E. A. ; Kartsova, L. A. .

In: Journal of Analytical Chemistry, Vol. 74, No. 6, 74, 2019, p. 570-573.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{997cf63d78dc4d3797536222253a4cf2,

title = "Characteristic Profiles of Biologically Active Substances of Blood Plasma Samples from Patients with Tuberculosis Obtained by HPLC",

abstract = "Toxic metabolites (N-acetylisoniazid, pyrazinoic acid, and desacetylrifampicin) of first-line anti-tuberculosis drugs (ethambutol, pyrazinamide, rifampicin, and isoniazid) are identified by liquid chromatography–mass spectrometry, which is important in selecting the required dosages of these drugs for the maximum therapeutic effects and the reduction of side effects. Characteristic chromatographic profiles of blood plasma samples from donors with pulmonary tuberculosis (“pathology”) and a clinically healthy group (“norm”) are obtained and processed by principal component analysis and the k-nearest neighbor method. A perspective of this approach for obtaining of additional diagnostic criteria for pulmonary tuberculosis is shown.",

keywords = "ВЭЖХ, биологически активные вещества, туберкулез, сыворотка крови, first-line anti-tuberculosis drugs, metabolites, HPLC–mass spectrometry, characteristic profiles of biologically active compounds, chemometrics",

author = "Solov{\textquoteright}eva, {S. A.} and Bessonova, {E. A.} and Kartsova, {L. A.}",

note = "Solov{\textquoteright}eva, S.A., Bessonova, E.A. & Kartsova, L.A. Characteristic Profiles of Biologically Active Substances of Blood Plasma Samples from Patients with Tuberculosis Obtained by HPLC. J Anal Chem 74, 570–573 (2019). https://doi.org/10.1134/S1061934819040142",

year = "2019",

doi = "DOI 10.1134/S1061934819040142",

language = "English",

volume = "74",

pages = "570--573",

journal = "Journal of Analytical Chemistry",

issn = "1061-9348",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "6",

}

RIS

TY - JOUR

T1 - Characteristic Profiles of Biologically Active Substances of Blood Plasma Samples from Patients with Tuberculosis Obtained by HPLC

AU - Solov’eva, S. A.

AU - Bessonova, E. A.

AU - Kartsova, L. A.

N1 - Solov’eva, S.A., Bessonova, E.A. & Kartsova, L.A. Characteristic Profiles of Biologically Active Substances of Blood Plasma Samples from Patients with Tuberculosis Obtained by HPLC. J Anal Chem 74, 570–573 (2019). https://doi.org/10.1134/S1061934819040142

PY - 2019

Y1 - 2019

N2 - Toxic metabolites (N-acetylisoniazid, pyrazinoic acid, and desacetylrifampicin) of first-line anti-tuberculosis drugs (ethambutol, pyrazinamide, rifampicin, and isoniazid) are identified by liquid chromatography–mass spectrometry, which is important in selecting the required dosages of these drugs for the maximum therapeutic effects and the reduction of side effects. Characteristic chromatographic profiles of blood plasma samples from donors with pulmonary tuberculosis (“pathology”) and a clinically healthy group (“norm”) are obtained and processed by principal component analysis and the k-nearest neighbor method. A perspective of this approach for obtaining of additional diagnostic criteria for pulmonary tuberculosis is shown.

AB - Toxic metabolites (N-acetylisoniazid, pyrazinoic acid, and desacetylrifampicin) of first-line anti-tuberculosis drugs (ethambutol, pyrazinamide, rifampicin, and isoniazid) are identified by liquid chromatography–mass spectrometry, which is important in selecting the required dosages of these drugs for the maximum therapeutic effects and the reduction of side effects. Characteristic chromatographic profiles of blood plasma samples from donors with pulmonary tuberculosis (“pathology”) and a clinically healthy group (“norm”) are obtained and processed by principal component analysis and the k-nearest neighbor method. A perspective of this approach for obtaining of additional diagnostic criteria for pulmonary tuberculosis is shown.

KW - ВЭЖХ, биологически активные вещества, туберкулез, сыворотка крови

KW - first-line anti-tuberculosis drugs

KW - metabolites

KW - HPLC–mass spectrometry

KW - characteristic profiles of biologically active compounds

KW - chemometrics

UR - https://link.springer.com/article/10.1134/S1061934819040142

U2 - DOI 10.1134/S1061934819040142

DO - DOI 10.1134/S1061934819040142

M3 - Article

VL - 74

SP - 570

EP - 573

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

SN - 1061-9348

IS - 6

M1 - 74

ER -

ID: 52420630