Chapter 5.1 Microdialysis in genetically altered animals. / Sotnikova, Tatyana D.; Gainetdinov, Raul R.
Handbook of Microdialysis Methods, Applications and Perspectives. ed. / Ben Westerink; Thomas Cremers. 2006. p. 399-417 (Handbook of Behavioral Neuroscience; Vol. 16).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
}
TY - CHAP
T1 - Chapter 5.1 Microdialysis in genetically altered animals
AU - Sotnikova, Tatyana D.
AU - Gainetdinov, Raul R.
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Recent advances in genetic approaches significantly extended horizon of opportunities to manipulate with expression of mammalian genes in vivo resulting in development of thousands of mouse strains carrying specific genetic alterations. Microdialysis shows a great utility to analyze consequences of such genetic manipulations on the processes governing synthesis, release, uptake, and neurotransmitter interactions in a physiologically or behaviorally relevant context. In this review, a history of microdialysis in mutant animals, practical considerations of microdialysis applications in mouse genetic models, and several examples of such applications are discussed. With the increasing power and fidelity of genetic manipulations and the development of uncountable number of various mutant mice, an explosion of studies using microdialysis in genetic models could be expected.
AB - Recent advances in genetic approaches significantly extended horizon of opportunities to manipulate with expression of mammalian genes in vivo resulting in development of thousands of mouse strains carrying specific genetic alterations. Microdialysis shows a great utility to analyze consequences of such genetic manipulations on the processes governing synthesis, release, uptake, and neurotransmitter interactions in a physiologically or behaviorally relevant context. In this review, a history of microdialysis in mutant animals, practical considerations of microdialysis applications in mouse genetic models, and several examples of such applications are discussed. With the increasing power and fidelity of genetic manipulations and the development of uncountable number of various mutant mice, an explosion of studies using microdialysis in genetic models could be expected.
UR - http://www.scopus.com/inward/record.url?scp=67649697252&partnerID=8YFLogxK
U2 - 10.1016/S1569-7339(06)16021-X
DO - 10.1016/S1569-7339(06)16021-X
M3 - Chapter
AN - SCOPUS:67649697252
SN - 9780444522764
T3 - Handbook of Behavioral Neuroscience
SP - 399
EP - 417
BT - Handbook of Microdialysis Methods, Applications and Perspectives
A2 - Westerink, Ben
A2 - Cremers, Thomas
ER -
ID: 36474674