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Changes in the Qualitative and Quantitative Composition of the Intestinal Microflora in Rats in Experimental Allergic Encephalomyelitis. / Abdurasulova, I. N.; Tarasova, E. A.; Matsulevich, A. V.; Eliseev, A. V.; Ermolenko, E. I.; Suvorov, A. N.; Klimenko, V. M.

In: Neuroscience and Behavioral Physiology, Vol. 47, No. 3, 01.03.2017, p. 328-336.

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Abdurasulova, I. N. ; Tarasova, E. A. ; Matsulevich, A. V. ; Eliseev, A. V. ; Ermolenko, E. I. ; Suvorov, A. N. ; Klimenko, V. M. / Changes in the Qualitative and Quantitative Composition of the Intestinal Microflora in Rats in Experimental Allergic Encephalomyelitis. In: Neuroscience and Behavioral Physiology. 2017 ; Vol. 47, No. 3. pp. 328-336.

BibTeX

@article{13f33f3bac504460a92ff998984a6e19,
title = "Changes in the Qualitative and Quantitative Composition of the Intestinal Microflora in Rats in Experimental Allergic Encephalomyelitis",
abstract = "We report here a study using a model of multiple sclerosis – experimental allergic encephalomyelitis (EAE) – to investigate changes in the qualitative and quantitative composition of the intestinal microbiota in rats with disease symptoms and with a symptom-free course. When clinical symptoms of EAE were apparent, there were changes in the composition of the microbiota of the gastrointestinal tract, with increases in the numbers of Gram-negative opportunistically pathogenic bacteria: Citrobacter spp., Klebsiella spp., and atypical E. coli. Rats without clinical signs of EAE were also found to have increased contents of Faecalibacterium prausnitzii. The significance of complexes changes in the composition of the intestinal microbiota is discussed, as this provides evidence of prolonged persistence of dysbacteriosis in rats on developing EAE.",
keywords = "autoimmune diseases, dysbiosis, experimental allergic encephalomyelitis, intestinal microbiota",
author = "Abdurasulova, {I. N.} and Tarasova, {E. A.} and Matsulevich, {A. V.} and Eliseev, {A. V.} and Ermolenko, {E. I.} and Suvorov, {A. N.} and Klimenko, {V. M.}",
note = "Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media New York. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2017",
month = mar,
day = "1",
doi = "10.1007/s11055-017-0401-7",
language = "English",
volume = "47",
pages = "328--336",
journal = "Neuroscience and Behavioral Physiology",
issn = "0097-0549",
publisher = "Springer Nature",
number = "3",

}

RIS

TY - JOUR

T1 - Changes in the Qualitative and Quantitative Composition of the Intestinal Microflora in Rats in Experimental Allergic Encephalomyelitis

AU - Abdurasulova, I. N.

AU - Tarasova, E. A.

AU - Matsulevich, A. V.

AU - Eliseev, A. V.

AU - Ermolenko, E. I.

AU - Suvorov, A. N.

AU - Klimenko, V. M.

N1 - Publisher Copyright: © 2017, Springer Science+Business Media New York. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - We report here a study using a model of multiple sclerosis – experimental allergic encephalomyelitis (EAE) – to investigate changes in the qualitative and quantitative composition of the intestinal microbiota in rats with disease symptoms and with a symptom-free course. When clinical symptoms of EAE were apparent, there were changes in the composition of the microbiota of the gastrointestinal tract, with increases in the numbers of Gram-negative opportunistically pathogenic bacteria: Citrobacter spp., Klebsiella spp., and atypical E. coli. Rats without clinical signs of EAE were also found to have increased contents of Faecalibacterium prausnitzii. The significance of complexes changes in the composition of the intestinal microbiota is discussed, as this provides evidence of prolonged persistence of dysbacteriosis in rats on developing EAE.

AB - We report here a study using a model of multiple sclerosis – experimental allergic encephalomyelitis (EAE) – to investigate changes in the qualitative and quantitative composition of the intestinal microbiota in rats with disease symptoms and with a symptom-free course. When clinical symptoms of EAE were apparent, there were changes in the composition of the microbiota of the gastrointestinal tract, with increases in the numbers of Gram-negative opportunistically pathogenic bacteria: Citrobacter spp., Klebsiella spp., and atypical E. coli. Rats without clinical signs of EAE were also found to have increased contents of Faecalibacterium prausnitzii. The significance of complexes changes in the composition of the intestinal microbiota is discussed, as this provides evidence of prolonged persistence of dysbacteriosis in rats on developing EAE.

KW - autoimmune diseases

KW - dysbiosis

KW - experimental allergic encephalomyelitis

KW - intestinal microbiota

UR - http://www.scopus.com/inward/record.url?scp=85014643835&partnerID=8YFLogxK

U2 - 10.1007/s11055-017-0401-7

DO - 10.1007/s11055-017-0401-7

M3 - Article

AN - SCOPUS:85014643835

VL - 47

SP - 328

EP - 336

JO - Neuroscience and Behavioral Physiology

JF - Neuroscience and Behavioral Physiology

SN - 0097-0549

IS - 3

ER -

ID: 27948181