Research output: Contribution to journal › Article › peer-review
Changes in the Qualitative and Quantitative Composition of the Intestinal Microflora in Rats in Experimental Allergic Encephalomyelitis. / Abdurasulova, I. N.; Tarasova, E. A.; Matsulevich, A. V.; Eliseev, A. V.; Ermolenko, E. I.; Suvorov, A. N.; Klimenko, V. M.
In: Neuroscience and Behavioral Physiology, Vol. 47, No. 3, 01.03.2017, p. 328-336.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Changes in the Qualitative and Quantitative Composition of the Intestinal Microflora in Rats in Experimental Allergic Encephalomyelitis
AU - Abdurasulova, I. N.
AU - Tarasova, E. A.
AU - Matsulevich, A. V.
AU - Eliseev, A. V.
AU - Ermolenko, E. I.
AU - Suvorov, A. N.
AU - Klimenko, V. M.
N1 - Publisher Copyright: © 2017, Springer Science+Business Media New York. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - We report here a study using a model of multiple sclerosis – experimental allergic encephalomyelitis (EAE) – to investigate changes in the qualitative and quantitative composition of the intestinal microbiota in rats with disease symptoms and with a symptom-free course. When clinical symptoms of EAE were apparent, there were changes in the composition of the microbiota of the gastrointestinal tract, with increases in the numbers of Gram-negative opportunistically pathogenic bacteria: Citrobacter spp., Klebsiella spp., and atypical E. coli. Rats without clinical signs of EAE were also found to have increased contents of Faecalibacterium prausnitzii. The significance of complexes changes in the composition of the intestinal microbiota is discussed, as this provides evidence of prolonged persistence of dysbacteriosis in rats on developing EAE.
AB - We report here a study using a model of multiple sclerosis – experimental allergic encephalomyelitis (EAE) – to investigate changes in the qualitative and quantitative composition of the intestinal microbiota in rats with disease symptoms and with a symptom-free course. When clinical symptoms of EAE were apparent, there were changes in the composition of the microbiota of the gastrointestinal tract, with increases in the numbers of Gram-negative opportunistically pathogenic bacteria: Citrobacter spp., Klebsiella spp., and atypical E. coli. Rats without clinical signs of EAE were also found to have increased contents of Faecalibacterium prausnitzii. The significance of complexes changes in the composition of the intestinal microbiota is discussed, as this provides evidence of prolonged persistence of dysbacteriosis in rats on developing EAE.
KW - autoimmune diseases
KW - dysbiosis
KW - experimental allergic encephalomyelitis
KW - intestinal microbiota
UR - http://www.scopus.com/inward/record.url?scp=85014643835&partnerID=8YFLogxK
U2 - 10.1007/s11055-017-0401-7
DO - 10.1007/s11055-017-0401-7
M3 - Article
AN - SCOPUS:85014643835
VL - 47
SP - 328
EP - 336
JO - Neuroscience and Behavioral Physiology
JF - Neuroscience and Behavioral Physiology
SN - 0097-0549
IS - 3
ER -
ID: 27948181