Research output: Contribution to journal › Article › peer-review
Cerebral toxoplasmosis in HIV-infected patients over 2015-2018 (a case study of Russia). / Azovtseva, O. V.; Bakulina, C. G.; Shelomov, A. S.; Trofimova, T. N.
In: Epidemiology and Infection, Vol. 148, 142, 2020.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Cerebral toxoplasmosis in HIV-infected patients over 2015-2018 (a case study of Russia)
AU - Azovtseva, O. V.
AU - Bakulina, C. G.
AU - Shelomov, A. S.
AU - Trofimova, T. N.
N1 - Publisher Copyright: © 2020 Cambridge University Press. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Cerebral toxoplasmosis is a leading cause of the central nervous system disorders in acquired immune deficiency syndrome (AIDS). This study aimed to investigate the clinical course of cerebral toxoplasmosis in human immunodeficiency virus (HIV)-infected individuals. The study included 90 HIV-infected patients with cerebral toxoplasmosis, who underwent inpatient treatment. In case of positive enzyme immunoassay, HIV infection was confirmed with the immunoblot test. The HIV-1 ribonucleic acid (RNA) level was determined using the polymerase chain reaction (PCR) method. The flow cytometry was used for counting CD4 (cluster of differentiation 4 cells). Pathomorphological examination included the autopsy, gross and microscopic examination of internal organs, histological and other methods. The incidence of cerebral toxoplasmosis significantly increases at the CD4 count below 100 cells/μl, p <0.001, and at the HIV viral load above 50 copies/ml, p <0.05. The clinical picture of cerebral toxoplasmosis included focal symptoms, cognitive impairment, toxic syndrome, mild cerebral symptoms, and a meningeal symptom. Given the absence of a specific clinical picture and the absence of abnormal laboratory and instrumental findings, the cerebral toxoplasmosis needs to be diagnosed with a number diagnostic methods combined: Clinical examination, laboratory testing, immunological examination, molecular genetic testing, and neuroradiological imaging.
AB - Cerebral toxoplasmosis is a leading cause of the central nervous system disorders in acquired immune deficiency syndrome (AIDS). This study aimed to investigate the clinical course of cerebral toxoplasmosis in human immunodeficiency virus (HIV)-infected individuals. The study included 90 HIV-infected patients with cerebral toxoplasmosis, who underwent inpatient treatment. In case of positive enzyme immunoassay, HIV infection was confirmed with the immunoblot test. The HIV-1 ribonucleic acid (RNA) level was determined using the polymerase chain reaction (PCR) method. The flow cytometry was used for counting CD4 (cluster of differentiation 4 cells). Pathomorphological examination included the autopsy, gross and microscopic examination of internal organs, histological and other methods. The incidence of cerebral toxoplasmosis significantly increases at the CD4 count below 100 cells/μl, p <0.001, and at the HIV viral load above 50 copies/ml, p <0.05. The clinical picture of cerebral toxoplasmosis included focal symptoms, cognitive impairment, toxic syndrome, mild cerebral symptoms, and a meningeal symptom. Given the absence of a specific clinical picture and the absence of abnormal laboratory and instrumental findings, the cerebral toxoplasmosis needs to be diagnosed with a number diagnostic methods combined: Clinical examination, laboratory testing, immunological examination, molecular genetic testing, and neuroradiological imaging.
KW - Cerebral toxoplasmosis
KW - Clinical picture
KW - HIV infection
KW - Medical imaging
KW - Pathoanatomy
KW - Humans
KW - Male
KW - Viral Load
KW - HIV Infections/complications
KW - Adult
KW - Female
KW - Russia/epidemiology
KW - AIDS-Related Opportunistic Infections/epidemiology
KW - Toxoplasmosis, Cerebral/complications
KW - pathoanatomy
KW - clinical picture
KW - medical imaging
UR - http://www.scopus.com/inward/record.url?scp=85086237920&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/623ec986-b2d6-3e34-902c-9cea6ff15fa9/
U2 - 10.1017/S0950268820000928
DO - 10.1017/S0950268820000928
M3 - Article
C2 - 32364106
AN - SCOPUS:85086237920
VL - 148
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
M1 - 142
ER -
ID: 70334296