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Cellular Mechanisms of Aortic Valve Calcification. / Zhiduleva, E. V.; Irtyuga, O. B.; Shishkova, A. A.; Ignat’eva, E. V.; Kostina, A. S.; Levchuk, K. A.; Golovkin, A. S.; Rylov, A. Yu; Kostareva, A. A.; Moiseeva, O. M.; Malashicheva, A. B.; Gordeev, M. L.

In: Bulletin of Experimental Biology and Medicine, Vol. 164, No. 3, 01.01.2018, p. 371-375.

Research output: Contribution to journal › Article › peer-review

Harvard

Zhiduleva, EV, Irtyuga, OB, Shishkova, AA, Ignat’eva, EV, Kostina, AS, Levchuk, KA, Golovkin, AS, Rylov, AY, Kostareva, AA, Moiseeva, OM, Malashicheva, AB & Gordeev, ML 2018, 'Cellular Mechanisms of Aortic Valve Calcification', Bulletin of Experimental Biology and Medicine, vol. 164, no. 3, pp. 371-375. https://doi.org/10.1007/s10517-018-3992-2

APA

Zhiduleva, E. V., Irtyuga, O. B., Shishkova, A. A., Ignat’eva, E. V., Kostina, A. S., Levchuk, K. A., Golovkin, A. S., Rylov, A. Y., Kostareva, A. A., Moiseeva, O. M., Malashicheva, A. B., & Gordeev, M. L. (2018). Cellular Mechanisms of Aortic Valve Calcification. Bulletin of Experimental Biology and Medicine, 164(3), 371-375. https://doi.org/10.1007/s10517-018-3992-2

Vancouver

Zhiduleva EV, Irtyuga OB, Shishkova AA, Ignat’eva EV, Kostina AS, Levchuk KA et al. Cellular Mechanisms of Aortic Valve Calcification. Bulletin of Experimental Biology and Medicine. 2018 Jan 1;164(3):371-375. https://doi.org/10.1007/s10517-018-3992-2

Author

Zhiduleva, E. V. ; Irtyuga, O. B. ; Shishkova, A. A. ; Ignat’eva, E. V. ; Kostina, A. S. ; Levchuk, K. A. ; Golovkin, A. S. ; Rylov, A. Yu ; Kostareva, A. A. ; Moiseeva, O. M. ; Malashicheva, A. B. ; Gordeev, M. L. / Cellular Mechanisms of Aortic Valve Calcification. In: Bulletin of Experimental Biology and Medicine. 2018 ; Vol. 164, No. 3. pp. 371-375.

BibTeX

@article{a90e298bfcde40f290c7b64e2be2c53a,
title = "Cellular Mechanisms of Aortic Valve Calcification",
abstract = "Comparative in vitro study examined the osteogenic potential of interstitial cells of aortic valve obtained from the patients with aortic stenosis and from control recipients of orthotopic heart transplantation with intact aortic valve. The osteogenic inductors augmented mineralization of aortic valve interstitial cells (AVIC) in patients with aortic stenosis in comparison with the control level. Native AVIC culture of aortic stenosis patients demonstrated overexpression of osteopontin gene (OPN) and underexpression of osteoprotegerin gene (OPG) in comparison with control levels. In both groups, AVIC differentiation was associated with overexpression of RUNX2 and SPRY1 genes. In AVIC of aortic stenosis patients, expression of BMP2 gene was significantly greater than the control level. The study revealed an enhanced sensitivity of AVIC to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN, OPG, and BMP2 genes in pathogenesis of aortic valve calcification.",
keywords = "aortic stenosis, aortic valve interstitial cells, osteogenic differentiation",
author = "Zhiduleva, {E. V.} and Irtyuga, {O. B.} and Shishkova, {A. A.} and Ignat{\textquoteright}eva, {E. V.} and Kostina, {A. S.} and Levchuk, {K. A.} and Golovkin, {A. S.} and Rylov, {A. Yu} and Kostareva, {A. A.} and Moiseeva, {O. M.} and Malashicheva, {A. B.} and Gordeev, {M. L.}",
year = "2018",
month = jan,
day = "1",
doi = "10.1007/s10517-018-3992-2",
language = "English",
volume = "164",
pages = "371--375",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer Nature",
number = "3",

}

RIS

TY - JOUR

T1 - Cellular Mechanisms of Aortic Valve Calcification

AU - Zhiduleva, E. V.

AU - Irtyuga, O. B.

AU - Shishkova, A. A.

AU - Ignat’eva, E. V.

AU - Kostina, A. S.

AU - Levchuk, K. A.

AU - Golovkin, A. S.

AU - Rylov, A. Yu

AU - Kostareva, A. A.

AU - Moiseeva, O. M.

AU - Malashicheva, A. B.

AU - Gordeev, M. L.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Comparative in vitro study examined the osteogenic potential of interstitial cells of aortic valve obtained from the patients with aortic stenosis and from control recipients of orthotopic heart transplantation with intact aortic valve. The osteogenic inductors augmented mineralization of aortic valve interstitial cells (AVIC) in patients with aortic stenosis in comparison with the control level. Native AVIC culture of aortic stenosis patients demonstrated overexpression of osteopontin gene (OPN) and underexpression of osteoprotegerin gene (OPG) in comparison with control levels. In both groups, AVIC differentiation was associated with overexpression of RUNX2 and SPRY1 genes. In AVIC of aortic stenosis patients, expression of BMP2 gene was significantly greater than the control level. The study revealed an enhanced sensitivity of AVIC to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN, OPG, and BMP2 genes in pathogenesis of aortic valve calcification.

AB - Comparative in vitro study examined the osteogenic potential of interstitial cells of aortic valve obtained from the patients with aortic stenosis and from control recipients of orthotopic heart transplantation with intact aortic valve. The osteogenic inductors augmented mineralization of aortic valve interstitial cells (AVIC) in patients with aortic stenosis in comparison with the control level. Native AVIC culture of aortic stenosis patients demonstrated overexpression of osteopontin gene (OPN) and underexpression of osteoprotegerin gene (OPG) in comparison with control levels. In both groups, AVIC differentiation was associated with overexpression of RUNX2 and SPRY1 genes. In AVIC of aortic stenosis patients, expression of BMP2 gene was significantly greater than the control level. The study revealed an enhanced sensitivity of AVIC to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN, OPG, and BMP2 genes in pathogenesis of aortic valve calcification.

KW - aortic stenosis

KW - aortic valve interstitial cells

KW - osteogenic differentiation

UR - http://www.scopus.com/inward/record.url?scp=85040440235&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/cellular-mechanisms-aortic-valve-calcification

U2 - 10.1007/s10517-018-3992-2

DO - 10.1007/s10517-018-3992-2

M3 - Article

C2 - 29308559

AN - SCOPUS:85040440235

VL - 164

SP - 371

EP - 375

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 3

ER -

ID: 35805688