Research output: Contribution to journal › Article › peer-review
CD68-Negative Histiocytoses with Cardiac Involvement, Associated with COVID-19. / Mitrofanova, L.; Korneva, L.; Makarov, I.; Bortsova, M.; Sitnikova, M.; Ryzhkova, D.; Kudlay, D.; Starshinova, A.
In: International Journal of Molecular Sciences, Vol. 25, No. 18, 10086, 19.09.2024.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - CD68-Negative Histiocytoses with Cardiac Involvement, Associated with COVID-19
AU - Mitrofanova, L.
AU - Korneva, L.
AU - Makarov, I.
AU - Bortsova, M.
AU - Sitnikova, M.
AU - Ryzhkova, D.
AU - Kudlay, D.
AU - Starshinova, A.
N1 - Export Date: 19 October 2024 Адрес для корреспонденции: Makarov, I.; Almazov National Medical Research CentreRussian Federation; эл. почта: makarov_ia@almazovcentre.ru Адрес для корреспонденции: Starshinova, A.; Almazov National Medical Research CentreRussian Federation; эл. почта: starshinova_aa@almazovcentre.ru Химические вещества/CAS: Antigens, CD; Antigens, Differentiation, Myelomonocytic; CD163 antigen; CD68 antigen, human; CD68 Molecule; Receptors, Cell Surface; Spike Glycoprotein, Coronavirus; spike protein, SARS-CoV-2
PY - 2024/9/19
Y1 - 2024/9/19
N2 - Histiocytoses are rare diseases characterised by infiltration of affected organs by myeloid cells with a monocyte or dendritic cell phenotype. Symptoms can range from self-resolving localised forms to multisystemic lesions requiring specific treatment. To demonstrate extremely rare cases of CD68-negative cardiac histiocytosis with expression of SARS-CoV-2 antigen in infiltrate cells. We demonstrated a case of Erdheim–Chester disease in a 67-year-old man with pericardial involvement and positive dynamics with vemurafenib treatment, an autopsy case of xanthogranulomatous myopericarditis in a 63-year-old man, surgical material of xanthogranulomatous constrictive pericarditis in a 57-year-old man, and an autopsy case of xanthogranulomatosis in a 1-month-old girl. In all cases, xanthogranuloma cells expressed CD163, many of them spike protein SARS-CoV-2, while CD68 expression was detected only in single cells. In this article, we demonstrated four cases of extremely rare CD68-negative cardiac xanthogranulomatosis in three adults and one child with expression of the spike protein SARS-CoV-2 in M2 macrophages. This potential indirect association between COVID-19 and the development of histiocytosis in these patients warrants further investigation. To substantiate this hypothesis, more extensive research is needed. © 2024 by the authors.
AB - Histiocytoses are rare diseases characterised by infiltration of affected organs by myeloid cells with a monocyte or dendritic cell phenotype. Symptoms can range from self-resolving localised forms to multisystemic lesions requiring specific treatment. To demonstrate extremely rare cases of CD68-negative cardiac histiocytosis with expression of SARS-CoV-2 antigen in infiltrate cells. We demonstrated a case of Erdheim–Chester disease in a 67-year-old man with pericardial involvement and positive dynamics with vemurafenib treatment, an autopsy case of xanthogranulomatous myopericarditis in a 63-year-old man, surgical material of xanthogranulomatous constrictive pericarditis in a 57-year-old man, and an autopsy case of xanthogranulomatosis in a 1-month-old girl. In all cases, xanthogranuloma cells expressed CD163, many of them spike protein SARS-CoV-2, while CD68 expression was detected only in single cells. In this article, we demonstrated four cases of extremely rare CD68-negative cardiac xanthogranulomatosis in three adults and one child with expression of the spike protein SARS-CoV-2 in M2 macrophages. This potential indirect association between COVID-19 and the development of histiocytosis in these patients warrants further investigation. To substantiate this hypothesis, more extensive research is needed. © 2024 by the authors.
KW - CD68
KW - COVID-19
KW - Erdheim–Chester disease
KW - myocarditis
KW - pericarditis
KW - xanthogranulomatosis
KW - CD163 antigen
KW - CD68 antigen
KW - CD68 antigen, human
KW - cell surface receptor
KW - coronavirus spike glycoprotein
KW - differentiation antigen
KW - leukocyte antigen
KW - spike protein, SARS-CoV-2
KW - aged
KW - case report
KW - complication
KW - coronavirus disease 2019
KW - diagnosis
KW - Erdheim Chester disease
KW - female
KW - histiocytosis
KW - human
KW - infant
KW - male
KW - metabolism
KW - middle aged
KW - pathology
KW - Severe acute respiratory syndrome coronavirus 2
KW - virology
KW - Aged
KW - Antigens, CD
KW - Antigens, Differentiation, Myelomonocytic
KW - CD68 Molecule
KW - Erdheim-Chester Disease
KW - Female
KW - Histiocytosis
KW - Humans
KW - Infant
KW - Male
KW - Middle Aged
KW - Receptors, Cell Surface
KW - SARS-CoV-2
KW - Spike Glycoprotein, Coronavirus
KW - Antigens, CD/metabolism
KW - COVID-19/metabolism
KW - Antigens, Differentiation, Myelomonocytic/metabolism
KW - Histiocytosis/pathology
KW - SARS-CoV-2/metabolism
KW - Spike Glycoprotein, Coronavirus/metabolism
KW - Erdheim-Chester Disease/metabolism
UR - https://www.mendeley.com/catalogue/d932b437-524a-37cd-9de4-7871ddcfce70/
U2 - 10.3390/ijms251810086
DO - 10.3390/ijms251810086
M3 - статья
C2 - 39337571
VL - 25
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 18
M1 - 10086
ER -
ID: 126387058