Can we gain translational insights into the functional roles of cerebral cortex from acortical rodent and naturally acortical zebrafish models?

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Can we gain translational insights into the functional roles of cerebral cortex from acortical rodent and naturally acortical zebrafish models? / Zabegalov, K.N.; Costa, F.V.; Kolesnikova, T.O.; de Abreu, M.S.; Petersen, E.V.; Yenkoyan, K.B.; Kalueff, A.V.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 132, 01.06.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{f1953c4e356a44d7834aeb2603a8ec8c,

title = "Can we gain translational insights into the functional roles of cerebral cortex from acortical rodent and naturally acortical zebrafish models?",

abstract = "Cerebral cortex is found only in mammals and is particularly prominent and developed in humans. Various rodent models with fully or partially ablated cortex are commonly used to probe the role of cortex in brain functions and its multiple subcortical projections, including pallium, thalamus and the limbic system. Various rodent models are traditionally used to study the role of cortex in brain functions. A small teleost fish, the zebrafish (Danio rerio), has gained popularity in neuroscience research, and albeit (like other fishes) lacking cortex, its brain performs well some key functions (e.g., memory, consciousness and motivation) with complex, context-specific and well-defined behaviors. Can rodent and zebrafish models help generate insights into the role of cortex in brain functions, and dissect its cortex-specific (vs. non-cortical) functions? To address this conceptual question, here we evaluate brain functionality in intact vs. decorticated rodents and further compare it in the zebrafish, a naturally occurring acortical species. Overall, comparing cortical and acortical rodent models with naturally acortical zebrafish reveals both distinct and overlapping contributions of neocortex and {\textquoteleft}precortical{\textquoteright} zebrafish telencephalic regions to higher brain functions. Albeit morphologically different, mammalian neocortex and fish pallium may possess more functional similarities than it is presently recognized, calling for further integrative research utilizing both cortical and decorticated/acortical vertebrate model organisms. {\textcopyright} 2024 Elsevier Inc.",

keywords = "CNS, Cortex, Decorticated models, Models, Zebrafish, animal experiment, animal model, animal tissue, brain cortex, brain function, central nervous system, consciousness, controlled study, embryo, human, limbic system, memory, neocortex, nonhuman, pharmacology, rat, review, rodent, telencephalon, teleost, thalamus, zebra fish",

author = "K.N. Zabegalov and F.V. Costa and T.O. Kolesnikova and {de Abreu}, M.S. and E.V. Petersen and K.B. Yenkoyan and A.V. Kalueff",

note = "Export Date: 21 March 2024 CODEN: PNPPD Адрес для корреспонденции: Yenkoyan, K.B.; Neuroscience Laboratory, Armenia; эл. почта: konstantin.yenkoyan@meduni.am Адрес для корреспонденции: Kalueff, A.V.; Neurobiology Program, Russian Federation; эл. почта: avkalueff@gmail.com Сведения о финансировании: Horizon 2020 Framework Programme, H2020, 857600 Сведения о финансировании: European Commission, EC Сведения о финансировании: Saint Petersburg State University, SPbU Сведения о финансировании: Suzhou University of Science and Technology Сведения о финансировании: State Committee of Science, SCS, 23LCG-3A020, 24YSMU-CON-I-3A Текст о финансировании 1: This work was supported by St. Petersburg State University funds. T.O.K. and F.V.C. were supported Sirius University of Science and Technology . K.B.Y. was supported by the Republic of Armenia State Committee of Science ( 24YSMU-CON-I-3A and 23LCG-3A020 ) and the European Union -funded H2020 COBRAIN project ( 857600 ). The funders had no role in the design, analyses, and interpretation of the submitted study, or decision to publish. Текст о финансировании 2: This work was supported by St. Petersburg State University funds. T.O.K. and F.V.C. were supported Sirius University of Science and Technology. K.B.Y. was supported by the Republic of Armenia State Committee of Science (24YSMU-CON-I-3A and 23LCG-3A020) and the European Union-funded H2020 COBRAIN project (857600). The funders had no role in the design, analyses, and interpretation of the submitted study, or decision to publish.",

year = "2024",

month = jun,

day = "1",

doi = "10.1016/j.pnpbp.2024.110964",

language = "Английский",

volume = "132",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier",