Bracteatinine and isogroenlandicine, two new isoquinoline alkaloids isolated from Corydalis bracteata and their effect on platelet function

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Bracteatinine and isogroenlandicine, two new isoquinoline alkaloids isolated from Corydalis bracteata and their effect on platelet function. / Whaley, Anastasiia O.; Whaley, Andrei K.; Toporkova, Valeria; Fock, Ekaterina; Rukoyatkina, Natalia; Smirnov, Sergey; Satimov, Gayrat B.; Abduraxmanov, Baxtiyar A.; Gambaryan, Stepan.

In: Fitoterapia, Vol. 171, 105697, 01.12.2023.

Research output: Contribution to journal › Article › peer-review

Author

Whaley, Anastasiia O. ; Whaley, Andrei K. ; Toporkova, Valeria ; Fock, Ekaterina ; Rukoyatkina, Natalia ; Smirnov, Sergey ; Satimov, Gayrat B. ; Abduraxmanov, Baxtiyar A. ; Gambaryan, Stepan. / Bracteatinine and isogroenlandicine, two new isoquinoline alkaloids isolated from Corydalis bracteata and their effect on platelet function. In: Fitoterapia. 2023 ; Vol. 171.

BibTeX

@article{06bbeb17c72649d39f76a5328f889ebe,

title = "Bracteatinine and isogroenlandicine, two new isoquinoline alkaloids isolated from Corydalis bracteata and their effect on platelet function",

abstract = "Two previously undescribed isoquinoline alkaloids, bracteatinine (1) and isogroenlandicine (2), together with four known alkaloids – coptisine (3), dehydrocorydaline (4), palmatine (5) and jatrorrhizine (6) were isolated from the aerial parts of Corydalis bracteata (Steph. Ex. Willd.) Pers. The structures of the compounds were elucidated using 1D and 2D NMR data along with HRESI-MS. The isolated new compounds bracteatinine and isogroenlandicine are close structural derivatives and isomers of corgoine and groenlandicine, respectively. Bracteatinine is also notable, being a representative of the rare 2-benzylisoquinoline alkaloids. Many natural products isolated from different plants are used as adjuvants, in addition to standard chemotherapy, in treatment of different cancers. Cancer-associated thrombosis remains a common complication and leading cause of mortality for cancer patients. Because platelets play the key role in thrombotic complications, we investigated effects of the isolated alkaloids 1–6 on platelet reactivity and showed that they did not significantly affect platelet function.",

keywords = "Corydalis bracteata, Benzylisoquinoline alkaloid, Protoberberine alkaloids, Platelet, Benzylisoquinoline alkaloid, Corydalis bracteata, Platelet, Protoberberine alkaloids",

author = "Whaley, {Anastasiia O.} and Whaley, {Andrei K.} and Valeria Toporkova and Ekaterina Fock and Natalia Rukoyatkina and Sergey Smirnov and Satimov, {Gayrat B.} and Abduraxmanov, {Baxtiyar A.} and Stepan Gambaryan",

year = "2023",

month = dec,

day = "1",

doi = "10.1016/j.fitote.2023.105697",

language = "English",

volume = "171",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Bracteatinine and isogroenlandicine, two new isoquinoline alkaloids isolated from Corydalis bracteata and their effect on platelet function

AU - Whaley, Anastasiia O.

AU - Whaley, Andrei K.

AU - Toporkova, Valeria

AU - Fock, Ekaterina

AU - Rukoyatkina, Natalia

AU - Smirnov, Sergey

AU - Satimov, Gayrat B.

AU - Abduraxmanov, Baxtiyar A.

AU - Gambaryan, Stepan

PY - 2023/12/1

Y1 - 2023/12/1

N2 - Two previously undescribed isoquinoline alkaloids, bracteatinine (1) and isogroenlandicine (2), together with four known alkaloids – coptisine (3), dehydrocorydaline (4), palmatine (5) and jatrorrhizine (6) were isolated from the aerial parts of Corydalis bracteata (Steph. Ex. Willd.) Pers. The structures of the compounds were elucidated using 1D and 2D NMR data along with HRESI-MS. The isolated new compounds bracteatinine and isogroenlandicine are close structural derivatives and isomers of corgoine and groenlandicine, respectively. Bracteatinine is also notable, being a representative of the rare 2-benzylisoquinoline alkaloids. Many natural products isolated from different plants are used as adjuvants, in addition to standard chemotherapy, in treatment of different cancers. Cancer-associated thrombosis remains a common complication and leading cause of mortality for cancer patients. Because platelets play the key role in thrombotic complications, we investigated effects of the isolated alkaloids 1–6 on platelet reactivity and showed that they did not significantly affect platelet function.

AB - Two previously undescribed isoquinoline alkaloids, bracteatinine (1) and isogroenlandicine (2), together with four known alkaloids – coptisine (3), dehydrocorydaline (4), palmatine (5) and jatrorrhizine (6) were isolated from the aerial parts of Corydalis bracteata (Steph. Ex. Willd.) Pers. The structures of the compounds were elucidated using 1D and 2D NMR data along with HRESI-MS. The isolated new compounds bracteatinine and isogroenlandicine are close structural derivatives and isomers of corgoine and groenlandicine, respectively. Bracteatinine is also notable, being a representative of the rare 2-benzylisoquinoline alkaloids. Many natural products isolated from different plants are used as adjuvants, in addition to standard chemotherapy, in treatment of different cancers. Cancer-associated thrombosis remains a common complication and leading cause of mortality for cancer patients. Because platelets play the key role in thrombotic complications, we investigated effects of the isolated alkaloids 1–6 on platelet reactivity and showed that they did not significantly affect platelet function.

KW - Corydalis bracteata

KW - Benzylisoquinoline alkaloid

KW - Protoberberine alkaloids

KW - Platelet

KW - Benzylisoquinoline alkaloid

KW - Corydalis bracteata

KW - Platelet

KW - Protoberberine alkaloids

UR - https://www.mendeley.com/catalogue/a3651c74-8c8b-395e-8f65-982284a79b61/

U2 - 10.1016/j.fitote.2023.105697

DO - 10.1016/j.fitote.2023.105697

M3 - Article

VL - 171

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

M1 - 105697

ER -

ID: 111852882