Research output: Contribution to journal › Literature review
Biomedical applications of capillary electrophoresis. / Kartsova, L.A.; Bessonova, E.A.
In: Russian Chemical Reviews, Vol. 84, No. 8, 2015, p. 860-874.Research output: Contribution to journal › Literature review
}
TY - JOUR
T1 - Biomedical applications of capillary electrophoresis
AU - Kartsova, L.A.
AU - Bessonova, E.A.
PY - 2015
Y1 - 2015
N2 - © 2015 Russian Academy of Sciences and Turpion Ltd.The review deals with modern analytical approaches used in capillary electrophoresis for solving medical and biological problems: search for biomarkers of various diseases and rapid diagnosis based on characteristic profiles of biologically active compounds by capillary electrophoresis with mass spectrometric detection; monitoring of the residual drugs in biological fluids for evaluating the efficiency of drug therapy; testing of the enantiomeric purity of pharmaceutical products; the use of novel materials as components of stationary and pseudo-stationary phases in capillary electrophoresis and capillary electrochromatography to increase the selectivity of separation of components of complex matrices; and identification of various on-line preconcentration techniques to reduce the detection limits of biologically active analytes. A topical trend in capillary electrophoresis required in clinical practice, viz., the design of microfluidic systems, is discussed.
AB - © 2015 Russian Academy of Sciences and Turpion Ltd.The review deals with modern analytical approaches used in capillary electrophoresis for solving medical and biological problems: search for biomarkers of various diseases and rapid diagnosis based on characteristic profiles of biologically active compounds by capillary electrophoresis with mass spectrometric detection; monitoring of the residual drugs in biological fluids for evaluating the efficiency of drug therapy; testing of the enantiomeric purity of pharmaceutical products; the use of novel materials as components of stationary and pseudo-stationary phases in capillary electrophoresis and capillary electrochromatography to increase the selectivity of separation of components of complex matrices; and identification of various on-line preconcentration techniques to reduce the detection limits of biologically active analytes. A topical trend in capillary electrophoresis required in clinical practice, viz., the design of microfluidic systems, is discussed.
U2 - 10.1070/RCR4492
DO - 10.1070/RCR4492
M3 - Literature review
VL - 84
SP - 860
EP - 874
JO - Russian Chemical Reviews
JF - Russian Chemical Reviews
SN - 0036-021X
IS - 8
ER -
ID: 4004144