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Biomarkers and potential targets for immune and cellular therapy in triple negative breast cancer. / Шемчук, Ольга Сергеевна; Семёнов, Константин Николаевич; Шаройко, Владимир Владимирович; Молчанов, Олег Евгеньевич; Майстренко, Дмитрий Николаевич; Гранов, Дмитрий; Васина, Любовь Васильевна; Попова, Алена; Василевская, Ирина; Миколайчук, Ольга Владиславовна; Попова, Елена; Протас, Александра Владимировна.

In: Cellular Therapy and Transplantation, Vol. 11, No. 2, 06.2022, p. 16-30.

Research output: Contribution to journal › Review article › peer-review

Harvard

Шемчук, ОС, Семёнов, КН, Шаройко, ВВ, Молчанов, ОЕ, Майстренко, ДН, Гранов, Д, Васина, ЛВ, Попова, А, Василевская, И, Миколайчук, ОВ, Попова, Е & Протас, АВ 2022, 'Biomarkers and potential targets for immune and cellular therapy in triple negative breast cancer', Cellular Therapy and Transplantation, vol. 11, no. 2, pp. 16-30. https://doi.org/10.18620/ctt-1866-8836-2022-11-2-16-30

APA

Шемчук, О. С., Семёнов, К. Н., Шаройко, В. В., Молчанов, О. Е., Майстренко, Д. Н., Гранов, Д., Васина, Л. В., Попова, А., Василевская, И., Миколайчук, О. В., Попова, Е., & Протас, А. В. (2022). Biomarkers and potential targets for immune and cellular therapy in triple negative breast cancer. Cellular Therapy and Transplantation, 11(2), 16-30. https://doi.org/10.18620/ctt-1866-8836-2022-11-2-16-30

Vancouver

Шемчук ОС, Семёнов КН, Шаройко ВВ, Молчанов ОЕ, Майстренко ДН, Гранов Д et al. Biomarkers and potential targets for immune and cellular therapy in triple negative breast cancer. Cellular Therapy and Transplantation. 2022 Jun;11(2):16-30. https://doi.org/10.18620/ctt-1866-8836-2022-11-2-16-30

Author

Шемчук, Ольга Сергеевна ; Семёнов, Константин Николаевич ; Шаройко, Владимир Владимирович ; Молчанов, Олег Евгеньевич ; Майстренко, Дмитрий Николаевич ; Гранов, Дмитрий ; Васина, Любовь Васильевна ; Попова, Алена ; Василевская, Ирина ; Миколайчук, Ольга Владиславовна ; Попова, Елена ; Протас, Александра Владимировна. / Biomarkers and potential targets for immune and cellular therapy in triple negative breast cancer. In: Cellular Therapy and Transplantation. 2022 ; Vol. 11, No. 2. pp. 16-30.

BibTeX

@article{8e3553de617e4dd08a9bf0a9ec0c22f7,
title = "Biomarkers and potential targets for immune and cellular therapy in triple negative breast cancer",
abstract = "Triple negative breast cancer (TNBC) is the most aggressive variant of breast malignancies, being a heterogeneous group with various molecular abnormalities that require differentiated approach to diagnosis and treatment. The article contains current data on modern molecular classifications of triple negative breast cancer and appropriate defects in signaling pathways as well as their assignment to distinct immunological and metabolic biomarkers. The data on the prognostic and predictive role of the tumor molecular biomarkers, as well as on clinically used and cellular therapy approaches and developing targeted drugs are presented, and the prospects for the future research are outlined. We also present the data of our own research concerning evaluation of the prognostic role of cytokines and lymphocyte subpopulations in peripheral blood of the TNBC patients.",
keywords = "Breast cancer, cellular microenvironment, cellular therapy, circulating tumor cells, interleukins, lymphocyte subpopu-lations, molecular subtypes, molecular targets, mu-tational burden, triple negative, tumor stem cells",
author = "Шемчук, {Ольга Сергеевна} and Семёнов, {Константин Николаевич} and Шаройко, {Владимир Владимирович} and Молчанов, {Олег Евгеньевич} and Майстренко, {Дмитрий Николаевич} and Дмитрий Гранов and Васина, {Любовь Васильевна} and Алена Попова and Ирина Василевская and Миколайчук, {Ольга Владиславовна} and Елена Попова and Протас, {Александра Владимировна}",
note = "Publisher Copyright: {\textcopyright} 2022, Universitatsklinikum Hamburg - Eppendorf. All rights reserved.",
year = "2022",
month = jun,
doi = "10.18620/ctt-1866-8836-2022-11-2-16-30",
language = "English",
volume = "11",
pages = "16--30",
journal = "Cellular Therapy and Transplantation",
issn = "1867-416X",
publisher = "Universitatsklinikum Hamburg - Eppendorf",
number = "2",

}

RIS

TY - JOUR

T1 - Biomarkers and potential targets for immune and cellular therapy in triple negative breast cancer

AU - Шемчук, Ольга Сергеевна

AU - Семёнов, Константин Николаевич

AU - Шаройко, Владимир Владимирович

AU - Молчанов, Олег Евгеньевич

AU - Майстренко, Дмитрий Николаевич

AU - Гранов, Дмитрий

AU - Васина, Любовь Васильевна

AU - Попова, Алена

AU - Василевская, Ирина

AU - Миколайчук, Ольга Владиславовна

AU - Попова, Елена

AU - Протас, Александра Владимировна

N1 - Publisher Copyright: © 2022, Universitatsklinikum Hamburg - Eppendorf. All rights reserved.

PY - 2022/6

Y1 - 2022/6

N2 - Triple negative breast cancer (TNBC) is the most aggressive variant of breast malignancies, being a heterogeneous group with various molecular abnormalities that require differentiated approach to diagnosis and treatment. The article contains current data on modern molecular classifications of triple negative breast cancer and appropriate defects in signaling pathways as well as their assignment to distinct immunological and metabolic biomarkers. The data on the prognostic and predictive role of the tumor molecular biomarkers, as well as on clinically used and cellular therapy approaches and developing targeted drugs are presented, and the prospects for the future research are outlined. We also present the data of our own research concerning evaluation of the prognostic role of cytokines and lymphocyte subpopulations in peripheral blood of the TNBC patients.

AB - Triple negative breast cancer (TNBC) is the most aggressive variant of breast malignancies, being a heterogeneous group with various molecular abnormalities that require differentiated approach to diagnosis and treatment. The article contains current data on modern molecular classifications of triple negative breast cancer and appropriate defects in signaling pathways as well as their assignment to distinct immunological and metabolic biomarkers. The data on the prognostic and predictive role of the tumor molecular biomarkers, as well as on clinically used and cellular therapy approaches and developing targeted drugs are presented, and the prospects for the future research are outlined. We also present the data of our own research concerning evaluation of the prognostic role of cytokines and lymphocyte subpopulations in peripheral blood of the TNBC patients.

KW - Breast cancer

KW - cellular microenvironment

KW - cellular therapy

KW - circulating tumor cells

KW - interleukins

KW - lymphocyte subpopu-lations

KW - molecular subtypes

KW - molecular targets

KW - mu-tational burden

KW - triple negative

KW - tumor stem cells

UR - https://www.mendeley.com/catalogue/9e7b53c3-af07-3be1-a38f-1ef7c1067bca/

UR - http://www.scopus.com/inward/record.url?scp=85137793315&partnerID=8YFLogxK

U2 - 10.18620/ctt-1866-8836-2022-11-2-16-30

DO - 10.18620/ctt-1866-8836-2022-11-2-16-30

M3 - Review article

VL - 11

SP - 16

EP - 30

JO - Cellular Therapy and Transplantation

JF - Cellular Therapy and Transplantation

SN - 1867-416X

IS - 2

ER -

ID: 98427474