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Biological safety and biodistribution of chitosan nanoparticles. / Sonin, Dmitry; Pochkaeva, Evgeniia; Zhuravskii, Sergei; Postnov, Viktor; Korolev, Dmitry; Vasina, Lyubov; Kostina, Daria; Mukhametdinova, Daria; Zelinskaya, Irina; Skorik, Yury; Naumysheva, Elena; Malashicheva, Anna; Somov, Pavel; Istomina, Maria; Rubanova, Natalia; Aleksandrov, Ilia; Vasyutina, Marina; Galagudza, Michael.

In: Nanomaterials, Vol. 10, No. 4, 810, 04.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Sonin, D, Pochkaeva, E, Zhuravskii, S, Postnov, V, Korolev, D, Vasina, L, Kostina, D, Mukhametdinova, D, Zelinskaya, I, Skorik, Y, Naumysheva, E, Malashicheva, A, Somov, P, Istomina, M, Rubanova, N, Aleksandrov, I, Vasyutina, M & Galagudza, M 2020, 'Biological safety and biodistribution of chitosan nanoparticles', Nanomaterials, vol. 10, no. 4, 810. https://doi.org/10.3390/nano10040810

APA

Sonin, D., Pochkaeva, E., Zhuravskii, S., Postnov, V., Korolev, D., Vasina, L., Kostina, D., Mukhametdinova, D., Zelinskaya, I., Skorik, Y., Naumysheva, E., Malashicheva, A., Somov, P., Istomina, M., Rubanova, N., Aleksandrov, I., Vasyutina, M., & Galagudza, M. (2020). Biological safety and biodistribution of chitosan nanoparticles. Nanomaterials, 10(4), [810]. https://doi.org/10.3390/nano10040810

Vancouver

Sonin D, Pochkaeva E, Zhuravskii S, Postnov V, Korolev D, Vasina L et al. Biological safety and biodistribution of chitosan nanoparticles. Nanomaterials. 2020 Apr;10(4). 810. https://doi.org/10.3390/nano10040810

Author

Sonin, Dmitry ; Pochkaeva, Evgeniia ; Zhuravskii, Sergei ; Postnov, Viktor ; Korolev, Dmitry ; Vasina, Lyubov ; Kostina, Daria ; Mukhametdinova, Daria ; Zelinskaya, Irina ; Skorik, Yury ; Naumysheva, Elena ; Malashicheva, Anna ; Somov, Pavel ; Istomina, Maria ; Rubanova, Natalia ; Aleksandrov, Ilia ; Vasyutina, Marina ; Galagudza, Michael. / Biological safety and biodistribution of chitosan nanoparticles. In: Nanomaterials. 2020 ; Vol. 10, No. 4.

BibTeX

@article{20b21ffe91344e8791ac383db24c47f5,
title = "Biological safety and biodistribution of chitosan nanoparticles",
abstract = "The effect of unmodified chitosan nanoparticles with a size of similar to 100 nm and a weakly positive charge on blood coagulation, metabolic activity of cultured cardiomyocytes, general toxicity, biodistribution, and reactive changes in rat organs in response to their single intravenous administration at doses of 1, 2, and 4 mg/kg was studied. Chitosan nanoparticles (CNPs) have a small cytotoxic effect and have a weak antiplatelet and anticoagulant effect. Intravenous administration of CNPs does not cause significant hemodynamic changes, and 30 min after the CNPs administration, they mainly accumulate in the liver and lungs, without causing hemolysis and leukocytosis. The toxicity of chitosan nanoparticles was manifested in a dose-dependent short-term delay in weight gain with subsequent recovery, while in the 2-week observation period no signs of pain and distress were observed in rats. Granulomas found in the lungs and liver indicate slow biodegradation of chitosan nanoparticles. In general, the obtained results indicate a good tolerance of intravenous administration of an unmodified chitosan suspension in the studied dose range.",
keywords = "Biodistribution, Blood compatibility, Chitosan, In vivo treatment, Polymer nanoparticles, Safety evaluation, chitosan, INDOCYANINE GREEN, BIOCOMPATIBILITY, polymer nanoparticles, biodistribution, MICELLES, blood compatibility, in vivo treatment, DELIVERY-SYSTEM, IN-VITRO, safety evaluation, PHARMACOKINETICS, N-SUCCINYL-CHITOSAN, LOADED NANOPARTICLES, DERIVATIVES, AGGREGATION",
author = "Dmitry Sonin and Evgeniia Pochkaeva and Sergei Zhuravskii and Viktor Postnov and Dmitry Korolev and Lyubov Vasina and Daria Kostina and Daria Mukhametdinova and Irina Zelinskaya and Yury Skorik and Elena Naumysheva and Anna Malashicheva and Pavel Somov and Maria Istomina and Natalia Rubanova and Ilia Aleksandrov and Marina Vasyutina and Michael Galagudza",
year = "2020",
month = apr,
doi = "10.3390/nano10040810",
language = "English",
volume = "10",
journal = "Nanomaterials",
issn = "2079-4991",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Biological safety and biodistribution of chitosan nanoparticles

AU - Sonin, Dmitry

AU - Pochkaeva, Evgeniia

AU - Zhuravskii, Sergei

AU - Postnov, Viktor

AU - Korolev, Dmitry

AU - Vasina, Lyubov

AU - Kostina, Daria

AU - Mukhametdinova, Daria

AU - Zelinskaya, Irina

AU - Skorik, Yury

AU - Naumysheva, Elena

AU - Malashicheva, Anna

AU - Somov, Pavel

AU - Istomina, Maria

AU - Rubanova, Natalia

AU - Aleksandrov, Ilia

AU - Vasyutina, Marina

AU - Galagudza, Michael

PY - 2020/4

Y1 - 2020/4

N2 - The effect of unmodified chitosan nanoparticles with a size of similar to 100 nm and a weakly positive charge on blood coagulation, metabolic activity of cultured cardiomyocytes, general toxicity, biodistribution, and reactive changes in rat organs in response to their single intravenous administration at doses of 1, 2, and 4 mg/kg was studied. Chitosan nanoparticles (CNPs) have a small cytotoxic effect and have a weak antiplatelet and anticoagulant effect. Intravenous administration of CNPs does not cause significant hemodynamic changes, and 30 min after the CNPs administration, they mainly accumulate in the liver and lungs, without causing hemolysis and leukocytosis. The toxicity of chitosan nanoparticles was manifested in a dose-dependent short-term delay in weight gain with subsequent recovery, while in the 2-week observation period no signs of pain and distress were observed in rats. Granulomas found in the lungs and liver indicate slow biodegradation of chitosan nanoparticles. In general, the obtained results indicate a good tolerance of intravenous administration of an unmodified chitosan suspension in the studied dose range.

AB - The effect of unmodified chitosan nanoparticles with a size of similar to 100 nm and a weakly positive charge on blood coagulation, metabolic activity of cultured cardiomyocytes, general toxicity, biodistribution, and reactive changes in rat organs in response to their single intravenous administration at doses of 1, 2, and 4 mg/kg was studied. Chitosan nanoparticles (CNPs) have a small cytotoxic effect and have a weak antiplatelet and anticoagulant effect. Intravenous administration of CNPs does not cause significant hemodynamic changes, and 30 min after the CNPs administration, they mainly accumulate in the liver and lungs, without causing hemolysis and leukocytosis. The toxicity of chitosan nanoparticles was manifested in a dose-dependent short-term delay in weight gain with subsequent recovery, while in the 2-week observation period no signs of pain and distress were observed in rats. Granulomas found in the lungs and liver indicate slow biodegradation of chitosan nanoparticles. In general, the obtained results indicate a good tolerance of intravenous administration of an unmodified chitosan suspension in the studied dose range.

KW - Biodistribution

KW - Blood compatibility

KW - Chitosan

KW - In vivo treatment

KW - Polymer nanoparticles

KW - Safety evaluation

KW - chitosan

KW - INDOCYANINE GREEN

KW - BIOCOMPATIBILITY

KW - polymer nanoparticles

KW - biodistribution

KW - MICELLES

KW - blood compatibility

KW - in vivo treatment

KW - DELIVERY-SYSTEM

KW - IN-VITRO

KW - safety evaluation

KW - PHARMACOKINETICS

KW - N-SUCCINYL-CHITOSAN

KW - LOADED NANOPARTICLES

KW - DERIVATIVES

KW - AGGREGATION

UR - http://www.scopus.com/inward/record.url?scp=85083863714&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/12879a27-12c9-318b-bda5-4b514c0a39fc/

U2 - 10.3390/nano10040810

DO - 10.3390/nano10040810

M3 - Article

AN - SCOPUS:85083863714

VL - 10

JO - Nanomaterials

JF - Nanomaterials

SN - 2079-4991

IS - 4

M1 - 810

ER -

ID: 53236845