Research output: Contribution to journal › Article › peer-review
A 1:1 reaction of 8-(dihydroimidazolyl)quinoline (abbreviated as L) with MCl 2 ·2H 2 O (M = Co II , Ni II , Cu II , Zn II ) conducted in EtOAc (for Zn II and Cu II ) or MeOH (Ni II and Co II ) at 50 °C for 10 min provided the respective air- and shelf-stable [MCl 2 L] complexes (94–96%). The catalytic activity of these well-defined species was evaluated in L-lactide ring-opening polymerization (ROP) that was conducted in the presence of 2-hydroxyethylmethacrylate (HEMA) as a nucleophilic initiator. The biocompatible zinc(II) complex was found to be more catalytically active in ROP compared to the other three complexes as well as SnOct 2 , a common reference catalyst. The zinc(II)-catalyzed ROP also gives the macromolecular product with the lowest polydispersity index (1.2). The applicability of the HEMA-terminated PLA, prepared in the presence of the [ZnCl 2 L] complex, was demonstrated when PLA was converted into amphiphilic copolymer PLA-PEG via the thiol-ene click reaction. The PLA-PEG copolymer was shown to form nanospheres (calculated mean diameter 95 ± 10 nm) characterized by low particle size distribution. This – along with anticipated lower toxicity of [ZnCl 2 L] traces in the polymer – makes these nanospheres potentially applicable as vehicles for intravenous drug delivery.
Original language | English |
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Pages (from-to) | 362-369 |
Number of pages | 8 |
Journal | Journal of Catalysis |
Volume | 372 |
DOIs | |
State | Published - 1 Apr 2019 |
ID: 40086073