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Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3. / Sharoyko, Vladimir V.; Iurev, Gleb O.; Postnov, Viktor N.; Meshcheriakov, Anatolii A.; Ageev, Sergei V.; Ivanova, Daria A.; Petrov, Andrey V.; Luttsev, Michail D.; Nashchekin, Alexei V.; Iamalova, Nailia R.; Vasina, Lubov V.; Solovtsova, Irina L.; Murin, Igor V.; Semenov, Konstantin N.

In: Journal of Biotechnology, Vol. 331, 01.04.2021, p. 83-98.

Research output: Contribution to journal › Article › peer-review

Harvard

Sharoyko, VV, Iurev, GO, Postnov, VN, Meshcheriakov, AA, Ageev, SV, Ivanova, DA, Petrov, AV, Luttsev, MD, Nashchekin, AV, Iamalova, NR, Vasina, LV, Solovtsova, IL, Murin, IV & Semenov, KN 2021, 'Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3', Journal of Biotechnology, vol. 331, pp. 83-98. https://doi.org/10.1016/j.jbiotec.2021.03.007

APA

Sharoyko, V. V., Iurev, G. O., Postnov, V. N., Meshcheriakov, A. A., Ageev, S. V., Ivanova, D. A., Petrov, A. V., Luttsev, M. D., Nashchekin, A. V., Iamalova, N. R., Vasina, L. V., Solovtsova, I. L., Murin, I. V., & Semenov, K. N. (2021). Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3. Journal of Biotechnology, 331, 83-98. https://doi.org/10.1016/j.jbiotec.2021.03.007

Vancouver

Sharoyko VV, Iurev GO, Postnov VN, Meshcheriakov AA, Ageev SV, Ivanova DA et al. Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3. Journal of Biotechnology. 2021 Apr 1;331:83-98. https://doi.org/10.1016/j.jbiotec.2021.03.007

Author

Sharoyko, Vladimir V. ; Iurev, Gleb O. ; Postnov, Viktor N. ; Meshcheriakov, Anatolii A. ; Ageev, Sergei V. ; Ivanova, Daria A. ; Petrov, Andrey V. ; Luttsev, Michail D. ; Nashchekin, Alexei V. ; Iamalova, Nailia R. ; Vasina, Lubov V. ; Solovtsova, Irina L. ; Murin, Igor V. ; Semenov, Konstantin N. / Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3. In: Journal of Biotechnology. 2021 ; Vol. 331. pp. 83-98.

BibTeX

@article{e8e1505e85ad4ce89ad74a36dd6e9b0e,
title = "Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3",
abstract = "Silica is silicon dioxide, which, depending on the production method, can exist in various amorphous forms with varying specific surface area, particle size, pore volume and size, and, as a result, with different physicochemical and sorption characteristics. The presence of silanol groups on the surface of silicas provides the possibility of its further functionalisation. In addition, the developed specific surface of Aerosil allows to obtain composites with a high content of biologically active substances. In this work, we studied the biocompatibility of a composite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3, namely: haemolysis (spontaneous and photoinduced), platelet aggregation, binding to HSA, cyto- and genotoxicity, antiradical activity. Interest in the creation of this nanomaterial is due to the fact that carboxylated fullerenes have potential applications in various fields of biomedicine, including the ability to bind reactive oxygen species, inhibition of tumour development, inactivation of viruses and bacteria. The obtained composite can be used for the immobilisation of various drugs and the further development of drugs for theranostics.",
keywords = "Aerosil, Carboxylated fullerene, Cytotoxicity, Genotoxicity, Haemocompatibility, Molecular dynamics, Reactive Oxygen Species, Carboxylic Acids, Nanocomposites, Silicon Dioxide, Fullerenes",
author = "Sharoyko, {Vladimir V.} and Iurev, {Gleb O.} and Postnov, {Viktor N.} and Meshcheriakov, {Anatolii A.} and Ageev, {Sergei V.} and Ivanova, {Daria A.} and Petrov, {Andrey V.} and Luttsev, {Michail D.} and Nashchekin, {Alexei V.} and Iamalova, {Nailia R.} and Vasina, {Lubov V.} and Solovtsova, {Irina L.} and Murin, {Igor V.} and Semenov, {Konstantin N.}",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = apr,
day = "1",
doi = "10.1016/j.jbiotec.2021.03.007",
language = "English",
volume = "331",
pages = "83--98",
journal = "Journal of Biotechnology",
issn = "0168-1656",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3

AU - Sharoyko, Vladimir V.

AU - Iurev, Gleb O.

AU - Postnov, Viktor N.

AU - Meshcheriakov, Anatolii A.

AU - Ageev, Sergei V.

AU - Ivanova, Daria A.

AU - Petrov, Andrey V.

AU - Luttsev, Michail D.

AU - Nashchekin, Alexei V.

AU - Iamalova, Nailia R.

AU - Vasina, Lubov V.

AU - Solovtsova, Irina L.

AU - Murin, Igor V.

AU - Semenov, Konstantin N.

N1 - Publisher Copyright: © 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Silica is silicon dioxide, which, depending on the production method, can exist in various amorphous forms with varying specific surface area, particle size, pore volume and size, and, as a result, with different physicochemical and sorption characteristics. The presence of silanol groups on the surface of silicas provides the possibility of its further functionalisation. In addition, the developed specific surface of Aerosil allows to obtain composites with a high content of biologically active substances. In this work, we studied the biocompatibility of a composite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3, namely: haemolysis (spontaneous and photoinduced), platelet aggregation, binding to HSA, cyto- and genotoxicity, antiradical activity. Interest in the creation of this nanomaterial is due to the fact that carboxylated fullerenes have potential applications in various fields of biomedicine, including the ability to bind reactive oxygen species, inhibition of tumour development, inactivation of viruses and bacteria. The obtained composite can be used for the immobilisation of various drugs and the further development of drugs for theranostics.

AB - Silica is silicon dioxide, which, depending on the production method, can exist in various amorphous forms with varying specific surface area, particle size, pore volume and size, and, as a result, with different physicochemical and sorption characteristics. The presence of silanol groups on the surface of silicas provides the possibility of its further functionalisation. In addition, the developed specific surface of Aerosil allows to obtain composites with a high content of biologically active substances. In this work, we studied the biocompatibility of a composite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3, namely: haemolysis (spontaneous and photoinduced), platelet aggregation, binding to HSA, cyto- and genotoxicity, antiradical activity. Interest in the creation of this nanomaterial is due to the fact that carboxylated fullerenes have potential applications in various fields of biomedicine, including the ability to bind reactive oxygen species, inhibition of tumour development, inactivation of viruses and bacteria. The obtained composite can be used for the immobilisation of various drugs and the further development of drugs for theranostics.

KW - Aerosil

KW - Carboxylated fullerene

KW - Cytotoxicity

KW - Genotoxicity

KW - Haemocompatibility

KW - Molecular dynamics

KW - Reactive Oxygen Species

KW - Carboxylic Acids

KW - Nanocomposites

KW - Silicon Dioxide

KW - Fullerenes

UR - http://www.scopus.com/inward/record.url?scp=85103119738&partnerID=8YFLogxK

U2 - 10.1016/j.jbiotec.2021.03.007

DO - 10.1016/j.jbiotec.2021.03.007

M3 - Article

C2 - 33727085

AN - SCOPUS:85103119738

VL - 331

SP - 83

EP - 98

JO - Journal of Biotechnology

JF - Journal of Biotechnology

SN - 0168-1656

ER -

ID: 77055653