Automated solid sample dissolution coupled with sugaring-out homogenous liquid-liquid extraction. Application for the analysis of throat lozenge samples

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Automated solid sample dissolution coupled with sugaring-out homogenous liquid-liquid extraction. Application for the analysis of throat lozenge samples. / Shishov, Andrey ; Nechaeva, Daria ; Moskvin, Leonid; Andruch, Vasil; Bulatov, Andrey.

In: Journal of Molecular Liquids, Vol. 233, 01.05.2017, p. 149-155.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{4ae94fe3f0c14392b55ce8d7de5d4557,

title = "Automated solid sample dissolution coupled with sugaring-out homogenous liquid-liquid extraction. Application for the analysis of throat lozenge samples",

abstract = "A novel automated procedure for analysis of solid samples based on the on-line dissolution of solid sample and sugaring-out reagent in water-acetonitrile mixture coupled with sugaring-out homogenous liquid-liquid extraction was developed. The procedure was performed in a mixing chamber of a stepwise injection analysis manifold. The performance of the suggested approach was demonstrated by the determination of 2,4-dichlorobenzyl alcohol, amylmetacresol, Yellow Orange S, Azo Rubine and Ponceau 4R in pharmaceutical samples. After phase separation, the upper acetonitrile phase containing 2,4-dichlorobenzyl alcohol, amylmetacresol and lower aqueous phase containing artificial dyes were sequentially analyzed. Under optimal experimental conditions the linear ranges were found to be 0.1–10 mg L− 1 for 2,4 dichlorobenzyl alcohol, 0.5–50 mg L− 1 for amylmetacresol, and 1–100 mg L− 1 for artificial dyes. The sample throughput was 10 h− 1. The proposed method was successfully applied for the automated analysis of commercial throat lozenges and the analytical results agreed fairly well with the results obtained by reference HPLC-UV method.",

keywords = "Automation, Flow analysis, Pharmaceuticals, Stepwise injection analysis, Sugaring-out homogenous liquid-liquid extraction",

author = "Andrey Shishov and Daria Nechaeva and Leonid Moskvin and Vasil Andruch and Andrey Bulatov",

year = "2017",

month = may,

day = "1",

doi = "10.1016/j.molliq.2017.03.022",

language = "English",

volume = "233",

pages = "149--155",

journal = "Journal of Molecular Liquids",

issn = "0167-7322",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Automated solid sample dissolution coupled with sugaring-out homogenous liquid-liquid extraction. Application for the analysis of throat lozenge samples

AU - Shishov, Andrey

AU - Nechaeva, Daria

AU - Moskvin, Leonid

AU - Andruch, Vasil

AU - Bulatov, Andrey

PY - 2017/5/1

Y1 - 2017/5/1

N2 - A novel automated procedure for analysis of solid samples based on the on-line dissolution of solid sample and sugaring-out reagent in water-acetonitrile mixture coupled with sugaring-out homogenous liquid-liquid extraction was developed. The procedure was performed in a mixing chamber of a stepwise injection analysis manifold. The performance of the suggested approach was demonstrated by the determination of 2,4-dichlorobenzyl alcohol, amylmetacresol, Yellow Orange S, Azo Rubine and Ponceau 4R in pharmaceutical samples. After phase separation, the upper acetonitrile phase containing 2,4-dichlorobenzyl alcohol, amylmetacresol and lower aqueous phase containing artificial dyes were sequentially analyzed. Under optimal experimental conditions the linear ranges were found to be 0.1–10 mg L− 1 for 2,4 dichlorobenzyl alcohol, 0.5–50 mg L− 1 for amylmetacresol, and 1–100 mg L− 1 for artificial dyes. The sample throughput was 10 h− 1. The proposed method was successfully applied for the automated analysis of commercial throat lozenges and the analytical results agreed fairly well with the results obtained by reference HPLC-UV method.

AB - A novel automated procedure for analysis of solid samples based on the on-line dissolution of solid sample and sugaring-out reagent in water-acetonitrile mixture coupled with sugaring-out homogenous liquid-liquid extraction was developed. The procedure was performed in a mixing chamber of a stepwise injection analysis manifold. The performance of the suggested approach was demonstrated by the determination of 2,4-dichlorobenzyl alcohol, amylmetacresol, Yellow Orange S, Azo Rubine and Ponceau 4R in pharmaceutical samples. After phase separation, the upper acetonitrile phase containing 2,4-dichlorobenzyl alcohol, amylmetacresol and lower aqueous phase containing artificial dyes were sequentially analyzed. Under optimal experimental conditions the linear ranges were found to be 0.1–10 mg L− 1 for 2,4 dichlorobenzyl alcohol, 0.5–50 mg L− 1 for amylmetacresol, and 1–100 mg L− 1 for artificial dyes. The sample throughput was 10 h− 1. The proposed method was successfully applied for the automated analysis of commercial throat lozenges and the analytical results agreed fairly well with the results obtained by reference HPLC-UV method.

KW - Automation

KW - Flow analysis

KW - Pharmaceuticals

KW - Stepwise injection analysis

KW - Sugaring-out homogenous liquid-liquid extraction

UR - http://www.scopus.com/inward/record.url?scp=85014811317&partnerID=8YFLogxK

U2 - 10.1016/j.molliq.2017.03.022

DO - 10.1016/j.molliq.2017.03.022

M3 - Article

AN - SCOPUS:85014811317

VL - 233

SP - 149

EP - 155

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

SN - 0167-7322

ER -

ID: 9160044