Association between polymorphisms in the dopamine transporter gene and depression : Evidence for a gene-environment interaction in a sample of juvenile detainees. / Haeffel, Gerald J.; Getchell, Marya; Koposov, Roman A.; Yrigollen, Carolyn M.; DeYoung, Colin G.; Af Klinteberg, Britt; Oreland, Lars; Ruchkin, Vladislav V.; Grigorenko, Elena L.
In: Psychological Science, Vol. 19, No. 1, 01.2008, p. 62-69.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Association between polymorphisms in the dopamine transporter gene and depression
T2 - Evidence for a gene-environment interaction in a sample of juvenile detainees
AU - Haeffel, Gerald J.
AU - Getchell, Marya
AU - Koposov, Roman A.
AU - Yrigollen, Carolyn M.
AU - DeYoung, Colin G.
AU - Af Klinteberg, Britt
AU - Oreland, Lars
AU - Ruchkin, Vladislav V.
AU - Grigorenko, Elena L.
N1 - Funding Information: the Natural Science Foundation of Jiangsu Province (BK20150053), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Collaborative Innovation Center of Suzhou Nano Science and Technology, and the Spanish Ministry of Economy, Industry and Competitiveness (national projects MAT2015-65525-R, FIS2014-60195-JIN, MAT2017-88358-C3-3-R, MAT2014-53432-C5-4-R, and the project MDM-2016-0618 of the Maria de Maeztu Units of Excellence Programme). Q.B. acknowledges support from the Australian Research Council (ARC) Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET). P.A.-G. acknowledges support from the European Research Council under Starting Grant 715496, 2DNANOPTICA. J.M.-S. acknowledges support through the Clarín Programme from the Government of the Principality of Asturias and a Marie Curie-COFUND grant (PA-18-ACB17-29). P.L. acknowledges support from a Marie Sklodowska-Cuire individual fellowship (SGPCM-705960). Funding Information: Acknowledgements We thank S. C. Dhanabalan and J. S. Ponraj for their efforts in the early stages of this project. We thank M. H. Lu, L. Liu, C. W. Qiu and L. Wang for suggestions, and H. Yan and Q. Xing for their assistance with micro-FTIR measurements. We thank Quantum Design China (Beijing laboratory) for technical support of some s-SNOM measurements. This work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). We acknowledge support from the National Natural Science Foundation of China (grant numbers 51222208, 51290273, 51601131, 61604102, 51702219 and 91433107), the Youth 973 programme (2015CB932700), the National Key Research and Development Program (2016YFA0201900), ARC (DP140101501, IH150100006, FT150100450 and CE170100039),
PY - 2008/1
Y1 - 2008/1
N2 - Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G × E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N = 176) recruited from a juvenile detention center in northern Russia. As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation. Further, this G × E interaction was specific to depression; it did not predict clinically significant anxiety. These results highlight the need for further research investigating the moderating effects of dopaminergic genes on depression.
AB - Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G × E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N = 176) recruited from a juvenile detention center in northern Russia. As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation. Further, this G × E interaction was specific to depression; it did not predict clinically significant anxiety. These results highlight the need for further research investigating the moderating effects of dopaminergic genes on depression.
UR - http://www.scopus.com/inward/record.url?scp=37549024565&partnerID=8YFLogxK
U2 - 10.1111/j.1467-9280.2008.02047.x
DO - 10.1111/j.1467-9280.2008.02047.x
M3 - Article
AN - SCOPUS:37549024565
VL - 19
SP - 62
EP - 69
JO - Psychological Science
JF - Psychological Science
SN - 0956-7976
IS - 1
ER -
ID: 87392444