Assessment of Contribution of Curie-Spin Mechanism in Proton Relaxation During Aggregation Process of Hemoglobin S

Standard

Assessment of Contribution of Curie-Spin Mechanism in Proton Relaxation During Aggregation Process of Hemoglobin S. / Cabal, C.; Lores, M.; Chizhik, V. I.; Rabdano, S. O.; García-Naranjo, J. C.

In: Applied Magnetic Resonance, Vol. 51, No. 12, 01.12.2020, p. 1647-1652.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{f5772ed74a09486d85dac2897863be07,

title = "Assessment of Contribution of Curie-Spin Mechanism in Proton Relaxation During Aggregation Process of Hemoglobin S",

abstract = "Previous works showed a significant increase in the rotational correlation time of the water bound to the hemoglobin S during the aggregation process under sickle cell disease. In this case, the contribution of “Curie-Spin” relaxation mechanism to proton relaxation may be expected. The Curie-Spin relaxation mechanism has been well described theoretically but only a few experimental evidences have been presented. Based on the reported correlation times, the contribution of the Curie-spin relaxation mechanism to proton relaxation times (T1 and T2) has been estimated in comparison with the contribution of the dipole–dipole relaxation mechanism at the extreme stages of the aggregation process of the hemoglobin S. This contribution is about 25% and 50% in the spin–spin relaxation rates at the magnetic field of 1.5 T during the latent and ending stages of the aggregation process, respectively. At lower magnetic fields, this mechanism gives an insignificant contribution. The contribution to the spin–lattice relaxation is negligible even at 1.5 T. In particular, this relaxation mechanism should be taken into account when interpreting experiments related to MRI.",

keywords = "NUCLEAR-RELAXATION, POLYMERIZATION, TIME, IONS, NMR",

author = "C. Cabal and M. Lores and Chizhik, {V. I.} and Rabdano, {S. O.} and Garc{\'i}a-Naranjo, {J. C.}",

year = "2020",

month = dec,

day = "1",

doi = "10.1007/s00723-020-01241-x",

language = "English",

volume = "51",

pages = "1647--1652",

journal = "Applied Magnetic Resonance",

issn = "0937-9347",

publisher = "Springer Nature",

number = "12",

}

RIS

TY - JOUR

T1 - Assessment of Contribution of Curie-Spin Mechanism in Proton Relaxation During Aggregation Process of Hemoglobin S

AU - Cabal, C.

AU - Lores, M.

AU - Chizhik, V. I.

AU - Rabdano, S. O.

AU - García-Naranjo, J. C.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Previous works showed a significant increase in the rotational correlation time of the water bound to the hemoglobin S during the aggregation process under sickle cell disease. In this case, the contribution of “Curie-Spin” relaxation mechanism to proton relaxation may be expected. The Curie-Spin relaxation mechanism has been well described theoretically but only a few experimental evidences have been presented. Based on the reported correlation times, the contribution of the Curie-spin relaxation mechanism to proton relaxation times (T1 and T2) has been estimated in comparison with the contribution of the dipole–dipole relaxation mechanism at the extreme stages of the aggregation process of the hemoglobin S. This contribution is about 25% and 50% in the spin–spin relaxation rates at the magnetic field of 1.5 T during the latent and ending stages of the aggregation process, respectively. At lower magnetic fields, this mechanism gives an insignificant contribution. The contribution to the spin–lattice relaxation is negligible even at 1.5 T. In particular, this relaxation mechanism should be taken into account when interpreting experiments related to MRI.

AB - Previous works showed a significant increase in the rotational correlation time of the water bound to the hemoglobin S during the aggregation process under sickle cell disease. In this case, the contribution of “Curie-Spin” relaxation mechanism to proton relaxation may be expected. The Curie-Spin relaxation mechanism has been well described theoretically but only a few experimental evidences have been presented. Based on the reported correlation times, the contribution of the Curie-spin relaxation mechanism to proton relaxation times (T1 and T2) has been estimated in comparison with the contribution of the dipole–dipole relaxation mechanism at the extreme stages of the aggregation process of the hemoglobin S. This contribution is about 25% and 50% in the spin–spin relaxation rates at the magnetic field of 1.5 T during the latent and ending stages of the aggregation process, respectively. At lower magnetic fields, this mechanism gives an insignificant contribution. The contribution to the spin–lattice relaxation is negligible even at 1.5 T. In particular, this relaxation mechanism should be taken into account when interpreting experiments related to MRI.

KW - NUCLEAR-RELAXATION

KW - POLYMERIZATION

KW - TIME

KW - IONS

KW - NMR

UR - http://www.scopus.com/inward/record.url?scp=85089990241&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/60a96840-6f09-3509-921c-5a91a816c016/

U2 - 10.1007/s00723-020-01241-x

DO - 10.1007/s00723-020-01241-x

M3 - Article

AN - SCOPUS:85089990241

VL - 51

SP - 1647

EP - 1652

JO - Applied Magnetic Resonance

JF - Applied Magnetic Resonance

SN - 0937-9347

IS - 12

ER -

ID: 62147083