Research output: Contribution to journal › Article › peer-review
Arene–Ruthenium(II) Complexes Containing 11H-Indeno[1,2-b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones. / Matveevskaya, Vladislava V. ; Pavlov, Dmitry I. ; Sukhikh, Taisiya S. ; Gushchin, Artem L. ; Ivanov, Alexander Yu. ; Tennikova, Tatiana B. ; Sharoyko, Vladimir V.; Baykov, Sergey V. ; Benassi, Enrico; Potapov, Andrei S. .
In: ACS Omega, Vol. 5, No. 19, 19.05.2020, p. 11167-11179.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Arene–Ruthenium(II) Complexes Containing 11H-Indeno[1,2-b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones
AU - Matveevskaya, Vladislava V.
AU - Pavlov, Dmitry I.
AU - Sukhikh, Taisiya S.
AU - Gushchin, Artem L.
AU - Ivanov, Alexander Yu.
AU - Tennikova, Tatiana B.
AU - Sharoyko, Vladimir V.
AU - Baykov, Sergey V.
AU - Benassi, Enrico
AU - Potapov, Andrei S.
N1 - Publisher Copyright: © 2020 American Chemical Society.
PY - 2020/5/19
Y1 - 2020/5/19
N2 - A series of novel mono- and binuclear arene–ruthenium(II) complexes [(p-cym)Ru(L)Cl] containing 11H-indeno[1,2-b]quinoxalin-11-one derivatives or tryptanthrin-6-oxime were synthesized and characterized by X-ray crystallography, IR, NMR spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical calculations invoking singlet state geometry optimization, solvation effects, and noncovalent interactions were done using density functional theory (DFT). DFT calculations were also applied to evaluate the electronic properties, and time-dependent DFT was applied to clarify experimental UV–vis results. Cytotoxicity for cancerous and noncancerous human cell lines was evaluated with cell viability MTT assay. Complexes demonstrated a moderate cytotoxic effect toward cancerous human cell line PANC-1. The catalytic activity of the complexes was evaluated in transfer hydrogenation of aryl ketones. All complexes exhibited good catalytic activity and functional group tolerance.
AB - A series of novel mono- and binuclear arene–ruthenium(II) complexes [(p-cym)Ru(L)Cl] containing 11H-indeno[1,2-b]quinoxalin-11-one derivatives or tryptanthrin-6-oxime were synthesized and characterized by X-ray crystallography, IR, NMR spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical calculations invoking singlet state geometry optimization, solvation effects, and noncovalent interactions were done using density functional theory (DFT). DFT calculations were also applied to evaluate the electronic properties, and time-dependent DFT was applied to clarify experimental UV–vis results. Cytotoxicity for cancerous and noncancerous human cell lines was evaluated with cell viability MTT assay. Complexes demonstrated a moderate cytotoxic effect toward cancerous human cell line PANC-1. The catalytic activity of the complexes was evaluated in transfer hydrogenation of aryl ketones. All complexes exhibited good catalytic activity and functional group tolerance.
KW - ARENE-RUTHENIUM COMPLEXES
KW - MOLECULAR-ORBITAL METHODS
KW - HIGHLY-ACTIVE CATALYSTS
KW - RUTHENIUM(II)-ARENE COMPLEXES
KW - ANTITUMOR-ACTIVITY
KW - BIOLOGICAL EVALUATION
KW - DENSITY FUNCTIONALS
KW - HUMAN OVARIAN
KW - BASIS-SETS
KW - IN-VITRO
UR - http://www.scopus.com/inward/record.url?scp=85084653075&partnerID=8YFLogxK
U2 - 10.1021/acsomega.0c01204
DO - 10.1021/acsomega.0c01204
M3 - Article
VL - 5
SP - 11167
EP - 11179
JO - ACS Omega
JF - ACS Omega
SN - 2470-1343
IS - 19
ER -
ID: 53561483