Anxiolytic-like effects of noribogaine in zebrafish

Standard

Anxiolytic-like effects of noribogaine in zebrafish. / Kalueff, Allan V.; Kaluyeva, Aleksandra; Mailet, Emeline L.

In: Behavioural Brain Research, Vol. 330, 14.07.2017, p. 63-67.

Research output: Contribution to journal › Article › peer-review

Author

Kalueff, Allan V. ; Kaluyeva, Aleksandra ; Mailet, Emeline L. / Anxiolytic-like effects of noribogaine in zebrafish. In: Behavioural Brain Research. 2017 ; Vol. 330. pp. 63-67.

BibTeX

@article{ea8a3760bd594b5988a4c7549684b2e6,

title = "Anxiolytic-like effects of noribogaine in zebrafish",

abstract = "Noribogaine is the main psychoactive metabolite of the hallucinogenic drug ibogaine, and is a particularly interesting compound potentially useful to treat dependence and various psychiatric disorders. Here, we report the effects of noribogaine on anxiety and locomotion in zebrafish (Danio rerio), a new promising model organism in neurobehavioral and psychopharmacological research. Adult zebrafish were subjected to the 5 min novel tank test (NTT) following an acute, 20-min drug immersion in 1, 5 and 10 mg/L noribogaine. Overall, noribogaine produced robust anxiolytic-like behavior in zebrafish (increasing the time spent and transitions to the top half compartment and reducing freezing bouts) without overt effects on fish locomotion. Taken together, these results indicate that noribogaine modulates the components of the acute stress response related to emotionality and anxiety behaviors, implicating this drug as a potentially useful non-sedative anxiolytic agent.",

keywords = "Anxiety, Drug abuse, Noribogaine, Zebrafish",

author = "Kalueff, {Allan V.} and Aleksandra Kaluyeva and Mailet, {Emeline L.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = jul,

day = "14",

doi = "10.1016/j.bbr.2017.05.008",

language = "English",

volume = "330",

pages = "63--67",

journal = "Behavioural Brain Research",

issn = "0166-4328",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Anxiolytic-like effects of noribogaine in zebrafish

AU - Kalueff, Allan V.

AU - Kaluyeva, Aleksandra

AU - Mailet, Emeline L.

PY - 2017/7/14

Y1 - 2017/7/14

N2 - Noribogaine is the main psychoactive metabolite of the hallucinogenic drug ibogaine, and is a particularly interesting compound potentially useful to treat dependence and various psychiatric disorders. Here, we report the effects of noribogaine on anxiety and locomotion in zebrafish (Danio rerio), a new promising model organism in neurobehavioral and psychopharmacological research. Adult zebrafish were subjected to the 5 min novel tank test (NTT) following an acute, 20-min drug immersion in 1, 5 and 10 mg/L noribogaine. Overall, noribogaine produced robust anxiolytic-like behavior in zebrafish (increasing the time spent and transitions to the top half compartment and reducing freezing bouts) without overt effects on fish locomotion. Taken together, these results indicate that noribogaine modulates the components of the acute stress response related to emotionality and anxiety behaviors, implicating this drug as a potentially useful non-sedative anxiolytic agent.

AB - Noribogaine is the main psychoactive metabolite of the hallucinogenic drug ibogaine, and is a particularly interesting compound potentially useful to treat dependence and various psychiatric disorders. Here, we report the effects of noribogaine on anxiety and locomotion in zebrafish (Danio rerio), a new promising model organism in neurobehavioral and psychopharmacological research. Adult zebrafish were subjected to the 5 min novel tank test (NTT) following an acute, 20-min drug immersion in 1, 5 and 10 mg/L noribogaine. Overall, noribogaine produced robust anxiolytic-like behavior in zebrafish (increasing the time spent and transitions to the top half compartment and reducing freezing bouts) without overt effects on fish locomotion. Taken together, these results indicate that noribogaine modulates the components of the acute stress response related to emotionality and anxiety behaviors, implicating this drug as a potentially useful non-sedative anxiolytic agent.

KW - Anxiety

KW - Drug abuse

KW - Noribogaine

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85019834438&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2017.05.008

DO - 10.1016/j.bbr.2017.05.008

M3 - Article

C2 - 28479267

AN - SCOPUS:85019834438

VL - 330

SP - 63

EP - 67

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -

ID: 97808934