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Antimicrobial activity of 5-membered nitroheteroaromatic compounds beyond nitrofurans and nitroimidazoles : Recent progress. / Kalinin, Stanislav; Vedekhina, Tatiana; Paramonova, Polina; Krasavin, Mikhail.

In: Current Medicinal Chemistry, Vol. 28, No. 29, 16.02.2021, p. 5926-5982.

Research output: Contribution to journal › Article › peer-review

Harvard

Kalinin, S, Vedekhina, T, Paramonova, P & Krasavin, M 2021, 'Antimicrobial activity of 5-membered nitroheteroaromatic compounds beyond nitrofurans and nitroimidazoles: Recent progress', Current Medicinal Chemistry, vol. 28, no. 29, pp. 5926-5982. https://doi.org/10.2174/0929867328666210216114838

APA

Kalinin, S., Vedekhina, T., Paramonova, P., & Krasavin, M. (2021). Antimicrobial activity of 5-membered nitroheteroaromatic compounds beyond nitrofurans and nitroimidazoles: Recent progress. Current Medicinal Chemistry, 28(29), 5926-5982. https://doi.org/10.2174/0929867328666210216114838

Vancouver

Kalinin S, Vedekhina T, Paramonova P, Krasavin M. Antimicrobial activity of 5-membered nitroheteroaromatic compounds beyond nitrofurans and nitroimidazoles: Recent progress. Current Medicinal Chemistry. 2021 Feb 16;28(29):5926-5982. https://doi.org/10.2174/0929867328666210216114838

Author

Kalinin, Stanislav ; Vedekhina, Tatiana ; Paramonova, Polina ; Krasavin, Mikhail. / Antimicrobial activity of 5-membered nitroheteroaromatic compounds beyond nitrofurans and nitroimidazoles : Recent progress. In: Current Medicinal Chemistry. 2021 ; Vol. 28, No. 29. pp. 5926-5982.

BibTeX

@article{0227a7399fc1472482dff9d664f2c50c,
title = "Antimicrobial activity of 5-membered nitroheteroaromatic compounds beyond nitrofurans and nitroimidazoles: Recent progress",
abstract = "The last decade has been characterized by the development and approval of pretomanid and delamanid, which are nitroimidazole based drugs for multidrug -resistant tuberculosis. This attracted renewed attention to the nitroheterocyclic scaffolds as a source of safe and efficient antimicrobial agents. While the primary focus is still on nitrofurans and nitroimidazoles, well known as bioreducible prodrugs, a number of studies have been published on other 5-membered nitroheteroaromatic compounds. The latter not only show promising antimicrobial activity but also demonstrate modes of action different from the conventional reductive activation of the nitro group. Considering the potential of these efforts to impact the continuing race against drug-resistant pathogens, herein we review non-furan/imidazole-based 5-membered nitroheteroaromatics investigated as antimicrobial agents in 2010-2020.",
keywords = "1,3,4-OXADIAZOLE DERIVATIVES, 2, 2-COMPONENT SIGNAL-TRANSDUCTION, 4-triazoles, DRUGS, GIARDICIDAL ACTIVITY, HELICOBACTER-PYLORI, IN-VITRO, Nitroaromatic heterocycles, OLD ANTIBIOTICS, REDUCTIVE ACTIVATION, RESEARCH-AND-DEVELOPMENT, TRICHOMONAS-VAGINALIS, antimicrobial agents, drug-resistant pathogens, microbial enzymes, nitro-1, nitro-thiazoles, nitroisoxazoles, nitropyrroles, nitrothiophenes, Humans, Nitroimidazoles/pharmacology, Nitrofurans/pharmacology, Anti-Infective Agents/pharmacology, Prodrugs, Tuberculosis, Multidrug-Resistant, Antitubercular Agents/pharmacology",
author = "Stanislav Kalinin and Tatiana Vedekhina and Polina Paramonova and Mikhail Krasavin",
note = "Stanislav Kalinin, Tatiana Vedekhina, Polina Paramonova and Mikhail Krasavin*, Antimicrobial Activity of 5-membered Nitroheteroaromatic Compounds beyond Nitrofurans and Nitroimidazoles: Recent Progress, Current Medicinal Chemistry 2021; 28(29) . https://dx.doi.org/10.2174/0929867328666210216114838",
year = "2021",
month = feb,
day = "16",
doi = "10.2174/0929867328666210216114838",
language = "English",
volume = "28",
pages = "5926--5982",
journal = "Current Medicinal Chemistry",
issn = "0929-8673",
publisher = "Bentham Science Publishers B.V.",
number = "29",

}

RIS

TY - JOUR

T1 - Antimicrobial activity of 5-membered nitroheteroaromatic compounds beyond nitrofurans and nitroimidazoles

T2 - Recent progress

AU - Kalinin, Stanislav

AU - Vedekhina, Tatiana

AU - Paramonova, Polina

AU - Krasavin, Mikhail

N1 - Stanislav Kalinin, Tatiana Vedekhina, Polina Paramonova and Mikhail Krasavin*, Antimicrobial Activity of 5-membered Nitroheteroaromatic Compounds beyond Nitrofurans and Nitroimidazoles: Recent Progress, Current Medicinal Chemistry 2021; 28(29) . https://dx.doi.org/10.2174/0929867328666210216114838

PY - 2021/2/16

Y1 - 2021/2/16

N2 - The last decade has been characterized by the development and approval of pretomanid and delamanid, which are nitroimidazole based drugs for multidrug -resistant tuberculosis. This attracted renewed attention to the nitroheterocyclic scaffolds as a source of safe and efficient antimicrobial agents. While the primary focus is still on nitrofurans and nitroimidazoles, well known as bioreducible prodrugs, a number of studies have been published on other 5-membered nitroheteroaromatic compounds. The latter not only show promising antimicrobial activity but also demonstrate modes of action different from the conventional reductive activation of the nitro group. Considering the potential of these efforts to impact the continuing race against drug-resistant pathogens, herein we review non-furan/imidazole-based 5-membered nitroheteroaromatics investigated as antimicrobial agents in 2010-2020.

AB - The last decade has been characterized by the development and approval of pretomanid and delamanid, which are nitroimidazole based drugs for multidrug -resistant tuberculosis. This attracted renewed attention to the nitroheterocyclic scaffolds as a source of safe and efficient antimicrobial agents. While the primary focus is still on nitrofurans and nitroimidazoles, well known as bioreducible prodrugs, a number of studies have been published on other 5-membered nitroheteroaromatic compounds. The latter not only show promising antimicrobial activity but also demonstrate modes of action different from the conventional reductive activation of the nitro group. Considering the potential of these efforts to impact the continuing race against drug-resistant pathogens, herein we review non-furan/imidazole-based 5-membered nitroheteroaromatics investigated as antimicrobial agents in 2010-2020.

KW - 1,3,4-OXADIAZOLE DERIVATIVES

KW - 2

KW - 2-COMPONENT SIGNAL-TRANSDUCTION

KW - 4-triazoles

KW - DRUGS

KW - GIARDICIDAL ACTIVITY

KW - HELICOBACTER-PYLORI

KW - IN-VITRO

KW - Nitroaromatic heterocycles

KW - OLD ANTIBIOTICS

KW - REDUCTIVE ACTIVATION

KW - RESEARCH-AND-DEVELOPMENT

KW - TRICHOMONAS-VAGINALIS

KW - antimicrobial agents

KW - drug-resistant pathogens

KW - microbial enzymes

KW - nitro-1

KW - nitro-thiazoles

KW - nitroisoxazoles

KW - nitropyrroles

KW - nitrothiophenes

KW - Humans

KW - Nitroimidazoles/pharmacology

KW - Nitrofurans/pharmacology

KW - Anti-Infective Agents/pharmacology

KW - Prodrugs

KW - Tuberculosis, Multidrug-Resistant

KW - Antitubercular Agents/pharmacology

UR - http://www.scopus.com/inward/record.url?scp=85115635200&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/a691db79-e034-3153-80e8-1a9ed2025042/

U2 - 10.2174/0929867328666210216114838

DO - 10.2174/0929867328666210216114838

M3 - Article

C2 - 33593249

VL - 28

SP - 5926

EP - 5982

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

SN - 0929-8673

IS - 29

ER -

ID: 85062562