Transformation of an Arctic aquatic ecosystem (a case study of Lake Imandra) under the impact of a mining industrial complex is considered. Water chemical composition and the ecosystem's structural components (phyto- and zooplankton, zoobenthos, and ichthiofauna) are analyzed for the following periods: the preindustrial background (reference) conditions, industrial development of mineral resources and strong anthropogenic impact, industrial recession and decreased anthropogenic impact, and stabilization. The main regularities of the aquatic ecosystem successions under the conditions of anthropogenic loads and their decrease are established.