Abstract: Ozone anomalies that occur in the winter–spring period in the Northern Hemisphere have been increasingly observed in recent decades not only in the polar, but also in midlatitudes, including those near populous cities. A decrease in the stratospheric ozone content can lead to dangerous for humans levels of UV radiation; therefore, the study of processes associated with the variability of the content of stratospheric ozone is an urgent task for developing methods to predict the appearance of ozone miniholes and the growth of UV surface illumination. Using the example of measurements of solar IR radiation with a Bruker 125HR Fourier spectrometer in the vicinity of St. Petersburg, we demonstrate the capabilities of the ground-based spectroscopic method for studying and explaining the temporal variability of stratospheric trace gases involved in the cycles of the destruction and formation of the ozone layer. We have shown the importance of the temperature and dynamic state of the stratosphere for the formation of conditions for the chemical destruction of ozone, as well as the efficiency of using measurements of the total HF content as a dynamic tracer that makes it possible to identify periods of potential activation of the chemical mechanism of ozone loss.