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An integrate-and-fire model for pulsatility in the neuroendocrine system. / Churilov, Alexander N. ; Milton, John; Salakhova, Elvira R. .

In: Chaos, Vol. 30, No. 8, 083132, 08.2020, p. 083132-083144.

Research output: Contribution to journal › Article › peer-review

Harvard

Churilov, AN, Milton, J & Salakhova, ER 2020, 'An integrate-and-fire model for pulsatility in the neuroendocrine system', Chaos, vol. 30, no. 8, 083132, pp. 083132-083144. https://doi.org/10.1063/5.0010553

APA

Churilov, A. N., Milton, J., & Salakhova, E. R. (2020). An integrate-and-fire model for pulsatility in the neuroendocrine system. Chaos, 30(8), 083132-083144. [083132]. https://doi.org/10.1063/5.0010553

Vancouver

Churilov AN, Milton J, Salakhova ER. An integrate-and-fire model for pulsatility in the neuroendocrine system. Chaos. 2020 Aug;30(8):083132-083144. 083132. https://doi.org/10.1063/5.0010553

Author

Churilov, Alexander N. ; Milton, John ; Salakhova, Elvira R. . / An integrate-and-fire model for pulsatility in the neuroendocrine system. In: Chaos. 2020 ; Vol. 30, No. 8. pp. 083132-083144.

BibTeX

@article{f13ffabaccb44cbb9885f490d90b90c5,
title = "An integrate-and-fire model for pulsatility in the neuroendocrine system",
abstract = "A model for pulsatility in neuroendocrine regulation is proposed which combines Goodwin-type feedback control with impulsive input from neurons located in the hypothalamus. The impulsive neural input is modeled using an integrate-and-fire mechanism; namely, inputs are generated only when the membrane potential crosses a threshold, after which it is reset to baseline. The resultant model takes the form of a functional-differential equation with continuous and impulsive components. Despite the impulsive nature of the inputs, realistic hormone profiles are generated, including ultradian and circadian rhythms, pulsatile secretory patterns, and even chaotic dynamics.",
keywords = "импульсные системы, Колебания, нейроэндокринная система, impulsive systems, oscillations, Neuroendocrinology, MENSTRUAL-CYCLE, NEURAL-CONTROL, BIOMATHEMATICAL MODEL, LUTEINIZING-HORMONE, MATHEMATICAL-MODEL, PITUITARY-GLAND, GROWTH-HORMONE, ELECTRICAL-STIMULATION, ENDOCRINE REGULATION, NEGATIVE-FEEDBACK",
author = "Churilov, {Alexander N.} and John Milton and Salakhova, {Elvira R.}",
note = "Publisher Copyright: {\textcopyright} 2020 Author(s).",
year = "2020",
month = aug,
doi = "10.1063/5.0010553",
language = "English",
volume = "30",
pages = "083132--083144",
journal = "Chaos",
issn = "1054-1500",
publisher = "American Institute of Physics",
number = "8",

}

RIS

TY - JOUR

T1 - An integrate-and-fire model for pulsatility in the neuroendocrine system

AU - Churilov, Alexander N.

AU - Milton, John

AU - Salakhova, Elvira R.

N1 - Publisher Copyright: © 2020 Author(s).

PY - 2020/8

Y1 - 2020/8

N2 - A model for pulsatility in neuroendocrine regulation is proposed which combines Goodwin-type feedback control with impulsive input from neurons located in the hypothalamus. The impulsive neural input is modeled using an integrate-and-fire mechanism; namely, inputs are generated only when the membrane potential crosses a threshold, after which it is reset to baseline. The resultant model takes the form of a functional-differential equation with continuous and impulsive components. Despite the impulsive nature of the inputs, realistic hormone profiles are generated, including ultradian and circadian rhythms, pulsatile secretory patterns, and even chaotic dynamics.

AB - A model for pulsatility in neuroendocrine regulation is proposed which combines Goodwin-type feedback control with impulsive input from neurons located in the hypothalamus. The impulsive neural input is modeled using an integrate-and-fire mechanism; namely, inputs are generated only when the membrane potential crosses a threshold, after which it is reset to baseline. The resultant model takes the form of a functional-differential equation with continuous and impulsive components. Despite the impulsive nature of the inputs, realistic hormone profiles are generated, including ultradian and circadian rhythms, pulsatile secretory patterns, and even chaotic dynamics.

KW - импульсные системы

KW - Колебания

KW - нейроэндокринная система

KW - impulsive systems

KW - oscillations

KW - Neuroendocrinology

KW - MENSTRUAL-CYCLE

KW - NEURAL-CONTROL

KW - BIOMATHEMATICAL MODEL

KW - LUTEINIZING-HORMONE

KW - MATHEMATICAL-MODEL

KW - PITUITARY-GLAND

KW - GROWTH-HORMONE

KW - ELECTRICAL-STIMULATION

KW - ENDOCRINE REGULATION

KW - NEGATIVE-FEEDBACK

UR - http://www.scopus.com/inward/record.url?scp=85090178868&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/dc0c2b10-4888-3da0-ad9e-ca0ef897f0fe/

U2 - 10.1063/5.0010553

DO - 10.1063/5.0010553

M3 - Article

VL - 30

SP - 83132

EP - 83144

JO - Chaos

JF - Chaos

SN - 1054-1500

IS - 8

M1 - 083132

ER -

ID: 61843791