The cyclodehydration of O-acylamidoximes at room temperature in the superbase system KOH/DMSO represents a simple and efficient way to 5-alkenyl- and 5-styryl-1,2,4-oxadiazoles. This method is suitable for the preparation of 5-(4-vinylphenyl)-1,2,4-oxadiazoles as well. Results of the antimicrobial tests demonstrated that the synthesized compounds exhibit a moderate antimicrobial effect against E.coli, S.aureus and C.albicans strains.
Original language
English
Pages (from-to)
458-470
Number of pages
13
Journal
Arkivoc
Volume
2018
Issue number
7
State
Published - Dec 2018
Research areas
Heterocycles, O-acylamidoximes, cyclodehydration, base catalysis, antimicrobial activity