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An application of the elastic net for an endophenotype analysis. / Palejev, Dean; Hwang, Wookyeon; Landi, Nicole; Eastman, Maria; Frost, Stephen J.; Fulbright, Robert K.; Kidd, Judith R.; Kidd, Kenneth K.; Mason, Graeme F.; Mencl, W. Einar; Yrigollen, Carolyn; Pugh, Kenneth R.; Grigorenko, Elena L.

In: Behavior Genetics, Vol. 41, No. 1, 01.2011, p. 120-124.

Research output: Contribution to journal › Article › peer-review

Harvard

Palejev, D, Hwang, W, Landi, N, Eastman, M, Frost, SJ, Fulbright, RK, Kidd, JR, Kidd, KK, Mason, GF, Mencl, WE, Yrigollen, C, Pugh, KR & Grigorenko, EL 2011, 'An application of the elastic net for an endophenotype analysis', Behavior Genetics, vol. 41, no. 1, pp. 120-124. https://doi.org/10.1007/s10519-011-9443-8

APA

Palejev, D., Hwang, W., Landi, N., Eastman, M., Frost, S. J., Fulbright, R. K., Kidd, J. R., Kidd, K. K., Mason, G. F., Mencl, W. E., Yrigollen, C., Pugh, K. R., & Grigorenko, E. L. (2011). An application of the elastic net for an endophenotype analysis. Behavior Genetics, 41(1), 120-124. https://doi.org/10.1007/s10519-011-9443-8

Vancouver

Palejev D, Hwang W, Landi N, Eastman M, Frost SJ, Fulbright RK et al. An application of the elastic net for an endophenotype analysis. Behavior Genetics. 2011 Jan;41(1):120-124. https://doi.org/10.1007/s10519-011-9443-8

Author

Palejev, Dean ; Hwang, Wookyeon ; Landi, Nicole ; Eastman, Maria ; Frost, Stephen J. ; Fulbright, Robert K. ; Kidd, Judith R. ; Kidd, Kenneth K. ; Mason, Graeme F. ; Mencl, W. Einar ; Yrigollen, Carolyn ; Pugh, Kenneth R. ; Grigorenko, Elena L. / An application of the elastic net for an endophenotype analysis. In: Behavior Genetics. 2011 ; Vol. 41, No. 1. pp. 120-124.

BibTeX

@article{13be179f8d564e418008cb1f7113a531,
title = "An application of the elastic net for an endophenotype analysis",
abstract = "We provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a critical area for reading, was obtained in a group (n = 76) of children aged 6-10 years. Two extreme groups, high and low, were selected for genotyping with the 650Y Illumina array chip (Ilmn650Y). An elastic net approach was applied to the resulting SNP dataset; 100 SNPs were identified for each chromosome as {"}interesting{"} based on having the highest absolute value coefficients. The analyses highlighted chromosomes 15 and 20, which contained 55 candidate genes. The STRING partner analyses of the associated proteins pointed to a number of related genes, most notably, GABA and NTRK receptors.",
keywords = "Elastic net, GABA concentration, Genetic association analysis, Occipital cortex, Reading acquisition",
author = "Dean Palejev and Wookyeon Hwang and Nicole Landi and Maria Eastman and Frost, {Stephen J.} and Fulbright, {Robert K.} and Kidd, {Judith R.} and Kidd, {Kenneth K.} and Mason, {Graeme F.} and Mencl, {W. Einar} and Carolyn Yrigollen and Pugh, {Kenneth R.} and Grigorenko, {Elena L.}",
note = "Funding Information: Acknowledgements Preparation of this article was supported in part by the following research grants from the National Institutes of Health: HD048830, HD001994, HD053409, AA009379, GM057672, HD052120, DC007665, and TW008274. Grantees undertaking such projects are encouraged to express their professional judgment freely. Therefore, this article does not necessarily reflect the position or policies of the National Institutes of Health, and no official endorsement should be inferred. We are thankful to Ms. Mei Tan for her editorial assistance.",
year = "2011",
month = jan,
doi = "10.1007/s10519-011-9443-8",
language = "English",
volume = "41",
pages = "120--124",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer Nature",
number = "1",

}

RIS

TY - JOUR

T1 - An application of the elastic net for an endophenotype analysis

AU - Palejev, Dean

AU - Hwang, Wookyeon

AU - Landi, Nicole

AU - Eastman, Maria

AU - Frost, Stephen J.

AU - Fulbright, Robert K.

AU - Kidd, Judith R.

AU - Kidd, Kenneth K.

AU - Mason, Graeme F.

AU - Mencl, W. Einar

AU - Yrigollen, Carolyn

AU - Pugh, Kenneth R.

AU - Grigorenko, Elena L.

N1 - Funding Information: Acknowledgements Preparation of this article was supported in part by the following research grants from the National Institutes of Health: HD048830, HD001994, HD053409, AA009379, GM057672, HD052120, DC007665, and TW008274. Grantees undertaking such projects are encouraged to express their professional judgment freely. Therefore, this article does not necessarily reflect the position or policies of the National Institutes of Health, and no official endorsement should be inferred. We are thankful to Ms. Mei Tan for her editorial assistance.

PY - 2011/1

Y1 - 2011/1

N2 - We provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a critical area for reading, was obtained in a group (n = 76) of children aged 6-10 years. Two extreme groups, high and low, were selected for genotyping with the 650Y Illumina array chip (Ilmn650Y). An elastic net approach was applied to the resulting SNP dataset; 100 SNPs were identified for each chromosome as "interesting" based on having the highest absolute value coefficients. The analyses highlighted chromosomes 15 and 20, which contained 55 candidate genes. The STRING partner analyses of the associated proteins pointed to a number of related genes, most notably, GABA and NTRK receptors.

AB - We provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a critical area for reading, was obtained in a group (n = 76) of children aged 6-10 years. Two extreme groups, high and low, were selected for genotyping with the 650Y Illumina array chip (Ilmn650Y). An elastic net approach was applied to the resulting SNP dataset; 100 SNPs were identified for each chromosome as "interesting" based on having the highest absolute value coefficients. The analyses highlighted chromosomes 15 and 20, which contained 55 candidate genes. The STRING partner analyses of the associated proteins pointed to a number of related genes, most notably, GABA and NTRK receptors.

KW - Elastic net

KW - GABA concentration

KW - Genetic association analysis

KW - Occipital cortex

KW - Reading acquisition

UR - http://www.scopus.com/inward/record.url?scp=79952446403&partnerID=8YFLogxK

U2 - 10.1007/s10519-011-9443-8

DO - 10.1007/s10519-011-9443-8

M3 - Article

C2 - 21229297

AN - SCOPUS:79952446403

VL - 41

SP - 120

EP - 124

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 1

ER -

ID: 87395456