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Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems : Investigations using a novel fungicide. / Knop, Katrin; Pavlov, Georges M.; Rudolph, Tobias; Martin, Karin; Pretzel, David; Jahn, Burkhard O.; Scharf, Daniel H.; Brakhage, Axel A.; Makarov, Vadim; Möllmann, Ute; Schacher, Felix H.; Schubert, Ulrich S.

In: Soft Matter, Vol. 9, No. 3, 21.01.2013, p. 715-726.

Research output: Contribution to journal › Article › peer-review

Harvard

Knop, K, Pavlov, GM, Rudolph, T, Martin, K, Pretzel, D, Jahn, BO, Scharf, DH, Brakhage, AA, Makarov, V, Möllmann, U, Schacher, FH & Schubert, US 2013, 'Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: Investigations using a novel fungicide', Soft Matter, vol. 9, no. 3, pp. 715-726. https://doi.org/10.1039/c2sm26509e

APA

Knop, K., Pavlov, G. M., Rudolph, T., Martin, K., Pretzel, D., Jahn, B. O., Scharf, D. H., Brakhage, A. A., Makarov, V., Möllmann, U., Schacher, F. H., & Schubert, U. S. (2013). Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: Investigations using a novel fungicide. Soft Matter, 9(3), 715-726. https://doi.org/10.1039/c2sm26509e

Vancouver

Knop K, Pavlov GM, Rudolph T, Martin K, Pretzel D, Jahn BO et al. Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: Investigations using a novel fungicide. Soft Matter. 2013 Jan 21;9(3):715-726. https://doi.org/10.1039/c2sm26509e

Author

Knop, Katrin ; Pavlov, Georges M. ; Rudolph, Tobias ; Martin, Karin ; Pretzel, David ; Jahn, Burkhard O. ; Scharf, Daniel H. ; Brakhage, Axel A. ; Makarov, Vadim ; Möllmann, Ute ; Schacher, Felix H. ; Schubert, Ulrich S. / Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems : Investigations using a novel fungicide. In: Soft Matter. 2013 ; Vol. 9, No. 3. pp. 715-726.

BibTeX

@article{6e3d383a47564200bcf364f58d735ca5,
title = "Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: Investigations using a novel fungicide",
abstract = "Amphiphilic star-shaped poly(ε-caprolactone)-block-poly(oligo(ethylene glycol)methacrylate) [PCLa-b-POEGMAb]4 block copolymers with four arms and varying degrees of polymerization for the core (PCL) and the shell (POEGMA) were used to investigate the solution behavior in dilute aqueous solution using a variety of techniques, including fluorescence and UV/Vis spectroscopy, dynamic light scattering, analytical ultracentrifugation, and isothermal titration calorimetry. Particular emphasis has been applied to prove that the systems form unimolecular micelles for different hydrophilic/lipophilic balances of the employed materials. In vitro cytotoxicity and hemocompatibility have further been investigated to probe the suitability of these structures for in vivo applications. A novel fungicide was included into the hydrophobic core in aqueous media to test their potential as drug delivery systems. After loading, the materials have been shown to release the drug and to provoke therewith an inhibition of the growth of different fungal strains.",
author = "Katrin Knop and Pavlov, {Georges M.} and Tobias Rudolph and Karin Martin and David Pretzel and Jahn, {Burkhard O.} and Scharf, {Daniel H.} and Brakhage, {Axel A.} and Vadim Makarov and Ute M{\"o}llmann and Schacher, {Felix H.} and Schubert, {Ulrich S.}",
year = "2013",
month = jan,
day = "21",
doi = "10.1039/c2sm26509e",
language = "English",
volume = "9",
pages = "715--726",
journal = "Soft Matter",
issn = "1744-683X",
publisher = "Royal Society of Chemistry",
number = "3",

}

RIS

TY - JOUR

T1 - Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems

T2 - Investigations using a novel fungicide

AU - Knop, Katrin

AU - Pavlov, Georges M.

AU - Rudolph, Tobias

AU - Martin, Karin

AU - Pretzel, David

AU - Jahn, Burkhard O.

AU - Scharf, Daniel H.

AU - Brakhage, Axel A.

AU - Makarov, Vadim

AU - Möllmann, Ute

AU - Schacher, Felix H.

AU - Schubert, Ulrich S.

PY - 2013/1/21

Y1 - 2013/1/21

N2 - Amphiphilic star-shaped poly(ε-caprolactone)-block-poly(oligo(ethylene glycol)methacrylate) [PCLa-b-POEGMAb]4 block copolymers with four arms and varying degrees of polymerization for the core (PCL) and the shell (POEGMA) were used to investigate the solution behavior in dilute aqueous solution using a variety of techniques, including fluorescence and UV/Vis spectroscopy, dynamic light scattering, analytical ultracentrifugation, and isothermal titration calorimetry. Particular emphasis has been applied to prove that the systems form unimolecular micelles for different hydrophilic/lipophilic balances of the employed materials. In vitro cytotoxicity and hemocompatibility have further been investigated to probe the suitability of these structures for in vivo applications. A novel fungicide was included into the hydrophobic core in aqueous media to test their potential as drug delivery systems. After loading, the materials have been shown to release the drug and to provoke therewith an inhibition of the growth of different fungal strains.

AB - Amphiphilic star-shaped poly(ε-caprolactone)-block-poly(oligo(ethylene glycol)methacrylate) [PCLa-b-POEGMAb]4 block copolymers with four arms and varying degrees of polymerization for the core (PCL) and the shell (POEGMA) were used to investigate the solution behavior in dilute aqueous solution using a variety of techniques, including fluorescence and UV/Vis spectroscopy, dynamic light scattering, analytical ultracentrifugation, and isothermal titration calorimetry. Particular emphasis has been applied to prove that the systems form unimolecular micelles for different hydrophilic/lipophilic balances of the employed materials. In vitro cytotoxicity and hemocompatibility have further been investigated to probe the suitability of these structures for in vivo applications. A novel fungicide was included into the hydrophobic core in aqueous media to test their potential as drug delivery systems. After loading, the materials have been shown to release the drug and to provoke therewith an inhibition of the growth of different fungal strains.

UR - http://www.scopus.com/inward/record.url?scp=84871224090&partnerID=8YFLogxK

U2 - 10.1039/c2sm26509e

DO - 10.1039/c2sm26509e

M3 - Article

AN - SCOPUS:84871224090

VL - 9

SP - 715

EP - 726

JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 3

ER -

ID: 97788188