Research output: Contribution to journal › Article › peer-review
Aminated graphene-graft-oligo(Glutamic acid) /poly(ε-caprolactone) composites : Preparation, characterization and biological evaluation. / Stepanova, Mariia; Solomakha, Olga; Rabchinskii, Maxim; Averianov, Ilia; Gofman, Iosif; Nashchekina, Yuliya; Antonov, Grigorii; Smirnov, Aleksey; Ber, Boris; Nashchekin, Aleksey; Korzhikova-Vlakh, Evgenia.
In: Polymers, Vol. 13, No. 16, 2628, 07.08.2021.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Aminated graphene-graft-oligo(Glutamic acid) /poly(ε-caprolactone) composites
T2 - Preparation, characterization and biological evaluation
AU - Stepanova, Mariia
AU - Solomakha, Olga
AU - Rabchinskii, Maxim
AU - Averianov, Ilia
AU - Gofman, Iosif
AU - Nashchekina, Yuliya
AU - Antonov, Grigorii
AU - Smirnov, Aleksey
AU - Ber, Boris
AU - Nashchekin, Aleksey
AU - Korzhikova-Vlakh, Evgenia
N1 - Stepanova, M.; Solomakha, O.; Rabchinskii, M.; Averianov, I.; Gofman, I.; Nashchekina, Y.; Antonov, G.; Smirnov, A.; Ber, B.; Nashchekin, A.; Korzhikova-Vlakh, E. Aminated Graphene-Graft-Oligo(Glutamic Acid) /Poly(ε-Caprolactone) Composites: Preparation, Characterization and Biological Evaluation. Polymers 2021, 13, 2628. https://doi.org/10.3390/polym13162628
PY - 2021/8/7
Y1 - 2021/8/7
N2 - Biodegradable and biocompatible composites are of great interest as biomedical materials for various regeneration processes such as the regeneration of bones, cartilage and soft tissues. Modification of the filler surface can improve its compatibility with the polymer matrix, and, as a result, the characteristics and properties of composite materials. This work is devoted to the synthesis and modification of aminated graphene with oligomers of glutamic acid and their use for the preparation of composite materials based on poly(ε-caprolactone). Ring-opening polymerization of N-carboxyanhydride of glutamic acid γ-benzyl ester was used to graft oligomers of glutamic acid from the surface of aminated graphene. The success of the modification was confirmed by Fourier-transform infrared and X-ray photoelectron spectroscopy as well as thermogravimetric analysis. In addition, the dispersions of neat and modified aminated graphene were analyzed by dynamic and electrophoretic light scattering to monitor changes in the characteristics due to modification. The poly(ε-caprolactone) films filled with neat and modified aminated graphene were manufactured and carefully characterized for their mechanical and biological properties. Grafting of glutamic acid oligomers from the surface of aminated graphene improved the distribution of the filler in the polymer matrix that, in turn, positively affected the mechanical properties of composite materials in comparison to ones containing the unmodified filler. Moreover, the modification improved the biocompatibility of the filler with human MG-63 osteoblast-like cells.
AB - Biodegradable and biocompatible composites are of great interest as biomedical materials for various regeneration processes such as the regeneration of bones, cartilage and soft tissues. Modification of the filler surface can improve its compatibility with the polymer matrix, and, as a result, the characteristics and properties of composite materials. This work is devoted to the synthesis and modification of aminated graphene with oligomers of glutamic acid and their use for the preparation of composite materials based on poly(ε-caprolactone). Ring-opening polymerization of N-carboxyanhydride of glutamic acid γ-benzyl ester was used to graft oligomers of glutamic acid from the surface of aminated graphene. The success of the modification was confirmed by Fourier-transform infrared and X-ray photoelectron spectroscopy as well as thermogravimetric analysis. In addition, the dispersions of neat and modified aminated graphene were analyzed by dynamic and electrophoretic light scattering to monitor changes in the characteristics due to modification. The poly(ε-caprolactone) films filled with neat and modified aminated graphene were manufactured and carefully characterized for their mechanical and biological properties. Grafting of glutamic acid oligomers from the surface of aminated graphene improved the distribution of the filler in the polymer matrix that, in turn, positively affected the mechanical properties of composite materials in comparison to ones containing the unmodified filler. Moreover, the modification improved the biocompatibility of the filler with human MG-63 osteoblast-like cells.
KW - Aminated graphene
KW - Biocompatible polymer composites
KW - Grafting from
KW - Graphene modification
KW - Oligomers of glutamic acid
KW - Poly-ε-caprolactone
KW - GRAPHENE OXIDE
KW - poly-epsilon-caprolactone
KW - SURFACE MODIFICATION
KW - graphene modification
KW - aminated graphene
KW - OSTEOGENESIS
KW - IN-VITRO
KW - grafting from
KW - biocompatible polymer composites
KW - oligomers of glutamic acid
KW - RING-OPENING POLYMERIZATION
KW - BIOMATERIALS
KW - SCAFFOLDS
KW - CELLULOSE
UR - http://www.scopus.com/inward/record.url?scp=85112774501&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/b93cb076-8269-315f-9ac0-3c74ce04e94a/
U2 - 10.3390/polym13162628
DO - 10.3390/polym13162628
M3 - Article
AN - SCOPUS:85112774501
VL - 13
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 16
M1 - 2628
ER -
ID: 84956047