Alteration of Time Intervals in Patients With Hypertrophic Cardiomyopathy During an Exercise Echocardiography. / Zagatina, Angela; Zhuravskaya, Nadezhda; Tyurina, Tatyana V.
In: Cardiology Research, Vol. 2, No. 2, 2011, p. 72-78.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Alteration of Time Intervals in Patients With Hypertrophic Cardiomyopathy During an Exercise Echocardiography
AU - Zagatina, Angela
AU - Zhuravskaya, Nadezhda
AU - Tyurina, Tatyana V
PY - 2011
Y1 - 2011
N2 - BACKGROUND: Hypertrophic cardiomyopathy (HCM) is often associated with diastolic dysfunction. Theoretically, a more marked alteration of diastolic function is revealed during exercise.METHODS AND RESULTS: We studied 84 persons: 1) 25 patients with HCM, 2) 25 patients with essential arterial hypertension (AH) and 3) 34 healthy controls. Each person performed a treadmill echocardiography. Before and after work, the following parameters were measured: the time interval between the QRS complex and the onset of mitral early diastolic filling velocity (TE), the interval between the QRS complex and the onset of peak early tissue mitral annular velocity (Te'), the isovolumetric relaxation time over the difference of TE and Te' ratio (IVRT/(TE-Te')), and changes of the time parameters during the stress test. In comparison with hypertensive and control groups, HCM patients at rest showed a significantly longer TE (448 ± 55 vs. 423 ± 33 vs. 417 ± 24 ms, P < 0.04) and Te' (446 ± 48 vs. 403 ± 44 vs. 416 ± 38 ms, P < 0.003). After stress the HCM group had a longer Te' (355 ± 59 vs. 299 ± 40 vs. 292 ± 30 ms, P < 0.000004) and a higher IVRT/(TE-Te') ratio (3.1 ± 1.5 vs. 0.9 ± 2.4 vs. 1.7 ± 1.2, P < 0.002).CONCLUSIONS: HCM patients show an alteration in the time parameters not only compared to healthy persons but to hypertensive patients as well.
AB - BACKGROUND: Hypertrophic cardiomyopathy (HCM) is often associated with diastolic dysfunction. Theoretically, a more marked alteration of diastolic function is revealed during exercise.METHODS AND RESULTS: We studied 84 persons: 1) 25 patients with HCM, 2) 25 patients with essential arterial hypertension (AH) and 3) 34 healthy controls. Each person performed a treadmill echocardiography. Before and after work, the following parameters were measured: the time interval between the QRS complex and the onset of mitral early diastolic filling velocity (TE), the interval between the QRS complex and the onset of peak early tissue mitral annular velocity (Te'), the isovolumetric relaxation time over the difference of TE and Te' ratio (IVRT/(TE-Te')), and changes of the time parameters during the stress test. In comparison with hypertensive and control groups, HCM patients at rest showed a significantly longer TE (448 ± 55 vs. 423 ± 33 vs. 417 ± 24 ms, P < 0.04) and Te' (446 ± 48 vs. 403 ± 44 vs. 416 ± 38 ms, P < 0.003). After stress the HCM group had a longer Te' (355 ± 59 vs. 299 ± 40 vs. 292 ± 30 ms, P < 0.000004) and a higher IVRT/(TE-Te') ratio (3.1 ± 1.5 vs. 0.9 ± 2.4 vs. 1.7 ± 1.2, P < 0.002).CONCLUSIONS: HCM patients show an alteration in the time parameters not only compared to healthy persons but to hypertensive patients as well.
U2 - 10.4021/cr35w
DO - 10.4021/cr35w
M3 - Article
C2 - 28348665
VL - 2
SP - 72
EP - 78
JO - Cardiology Research
JF - Cardiology Research
SN - 1923-2829
IS - 2
ER -
ID: 43614025