Research output: Contribution to journal › Article
Alkylation of 5-substituted NH-tetrazoles by alcohols in the superacid CF3SO3H. / Lisakova, A.D.; Ryabukhin, D.S.; Trifonov, R.E.; Ostrovskii, V.A.; Vasilyev, A.V.
In: Tetrahedron Letters, Vol. 56, No. 50, 2015, p. 7020-7023.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Alkylation of 5-substituted NH-tetrazoles by alcohols in the superacid CF3SO3H
AU - Lisakova, A.D.
AU - Ryabukhin, D.S.
AU - Trifonov, R.E.
AU - Ostrovskii, V.A.
AU - Vasilyev, A.V.
PY - 2015
Y1 - 2015
N2 - © 2015 Elsevier Ltd.Reactions of 5-substituted NH-tetrazoles with alcohols in the superacid CF3SO3H have been studied. Both the structure of the tetrazole and the nature of alcohol were found to dramatically influence the selectivity of the reaction and yields of products. Tetrazoles bearing phenyl, electron-donating aryl, or benzyl groups at the 5-position, have been alkylated using various alcohols (including MeOH and EtOH) in CF3SO3H upon heating at 60 °C for 0.3-12 h to afford 2-alkyl-2H-tetrazoles in 30-98% yields.
AB - © 2015 Elsevier Ltd.Reactions of 5-substituted NH-tetrazoles with alcohols in the superacid CF3SO3H have been studied. Both the structure of the tetrazole and the nature of alcohol were found to dramatically influence the selectivity of the reaction and yields of products. Tetrazoles bearing phenyl, electron-donating aryl, or benzyl groups at the 5-position, have been alkylated using various alcohols (including MeOH and EtOH) in CF3SO3H upon heating at 60 °C for 0.3-12 h to afford 2-alkyl-2H-tetrazoles in 30-98% yields.
U2 - 10.1016/j.tetlet.2015.11.005
DO - 10.1016/j.tetlet.2015.11.005
M3 - Article
VL - 56
SP - 7020
EP - 7023
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 50
ER -
ID: 3979051