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Aktivnost' piruvat- i ketoglutaratdegidrogenaznogo kompleksov v razlichnykh otdelakh golovnogo mozga krys. / Rozanov, V. A.; Parkhomenko, I. M.

In: Ukrainskii biokhimicheskii zhurnal, Vol. 59, No. 1, 01.01.1987, p. 29-34.

Research output: Contribution to journal › Article › peer-review

Harvard

Rozanov, VA & Parkhomenko, IM 1987, 'Aktivnost' piruvat- i ketoglutaratdegidrogenaznogo kompleksov v razlichnykh otdelakh golovnogo mozga krys.', Ukrainskii biokhimicheskii zhurnal, vol. 59, no. 1, pp. 29-34.

APA

Rozanov, V. A., & Parkhomenko, I. M. (1987). Aktivnost' piruvat- i ketoglutaratdegidrogenaznogo kompleksov v razlichnykh otdelakh golovnogo mozga krys. Ukrainskii biokhimicheskii zhurnal, 59(1), 29-34.

Vancouver

Rozanov VA, Parkhomenko IM. Aktivnost' piruvat- i ketoglutaratdegidrogenaznogo kompleksov v razlichnykh otdelakh golovnogo mozga krys. Ukrainskii biokhimicheskii zhurnal. 1987 Jan 1;59(1):29-34.

Author

Rozanov, V. A. ; Parkhomenko, I. M. / Aktivnost' piruvat- i ketoglutaratdegidrogenaznogo kompleksov v razlichnykh otdelakh golovnogo mozga krys. In: Ukrainskii biokhimicheskii zhurnal. 1987 ; Vol. 59, No. 1. pp. 29-34.

BibTeX

@article{dadbee9c93e14b9785d2f2ea435aaca7,
title = "Aktivnost' piruvat- i ketoglutaratdegidrogenaznogo kompleksov v razlichnykh otdelakh golovnogo mozga krys.",
abstract = "The activity of pyruvate dehydrogenase and ketoglutarate dehydrogenase complexes (PDC; EC 1.2.4.1 and KDC; EC 1.2.4.2, respectively) was studied in extracts and lysates of mitochondria isolated from the cortex, cerebellum and stem of the rat brain. In all the mentioned cerebral areas the PDC activity calculating per 1 mg protein noticeably increased that for KDC. Under conditions of solubilization the activity of KDC lowered to a greater extent than that of PDC. The studied brain areas are arranged according to the activity of PDC and KDC in lysates in the following order: stem much much greater than cortex greater than cerebellum, however, the highest stock of the PDC activity manifesting with activation of endogenous phosphatase and dephosphorylation of the complex is observed in cerebellum. When calculating per mitochondria isolated from 1 g of tissue, the value of the PDC activity/KDC activity ratio in all areas of the brain is more than 1, and in cerebellum allowing for the complete PDC activity it exceeds 3. The data obtained emphasize the biochemical originality of the cerebellum and the presence of specific peculiarities in regulation of the pyruvate dehydrogenase complex activity in this cerebral area.",
author = "Rozanov, {V. A.} and Parkhomenko, {I. M.}",
year = "1987",
month = jan,
day = "1",
language = "русский",
volume = "59",
pages = "29--34",
journal = "Ukrainian biochemical journal",
issn = "2409-4943",
publisher = "Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine (NASU)",
number = "1",

}

RIS

TY - JOUR

T1 - Aktivnost' piruvat- i ketoglutaratdegidrogenaznogo kompleksov v razlichnykh otdelakh golovnogo mozga krys.

AU - Rozanov, V. A.

AU - Parkhomenko, I. M.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The activity of pyruvate dehydrogenase and ketoglutarate dehydrogenase complexes (PDC; EC 1.2.4.1 and KDC; EC 1.2.4.2, respectively) was studied in extracts and lysates of mitochondria isolated from the cortex, cerebellum and stem of the rat brain. In all the mentioned cerebral areas the PDC activity calculating per 1 mg protein noticeably increased that for KDC. Under conditions of solubilization the activity of KDC lowered to a greater extent than that of PDC. The studied brain areas are arranged according to the activity of PDC and KDC in lysates in the following order: stem much much greater than cortex greater than cerebellum, however, the highest stock of the PDC activity manifesting with activation of endogenous phosphatase and dephosphorylation of the complex is observed in cerebellum. When calculating per mitochondria isolated from 1 g of tissue, the value of the PDC activity/KDC activity ratio in all areas of the brain is more than 1, and in cerebellum allowing for the complete PDC activity it exceeds 3. The data obtained emphasize the biochemical originality of the cerebellum and the presence of specific peculiarities in regulation of the pyruvate dehydrogenase complex activity in this cerebral area.

AB - The activity of pyruvate dehydrogenase and ketoglutarate dehydrogenase complexes (PDC; EC 1.2.4.1 and KDC; EC 1.2.4.2, respectively) was studied in extracts and lysates of mitochondria isolated from the cortex, cerebellum and stem of the rat brain. In all the mentioned cerebral areas the PDC activity calculating per 1 mg protein noticeably increased that for KDC. Under conditions of solubilization the activity of KDC lowered to a greater extent than that of PDC. The studied brain areas are arranged according to the activity of PDC and KDC in lysates in the following order: stem much much greater than cortex greater than cerebellum, however, the highest stock of the PDC activity manifesting with activation of endogenous phosphatase and dephosphorylation of the complex is observed in cerebellum. When calculating per mitochondria isolated from 1 g of tissue, the value of the PDC activity/KDC activity ratio in all areas of the brain is more than 1, and in cerebellum allowing for the complete PDC activity it exceeds 3. The data obtained emphasize the biochemical originality of the cerebellum and the presence of specific peculiarities in regulation of the pyruvate dehydrogenase complex activity in this cerebral area.

UR - http://www.scopus.com/inward/record.url?scp=0023242039&partnerID=8YFLogxK

M3 - статья

C2 - 3810887

AN - SCOPUS:0023242039

VL - 59

SP - 29

EP - 34

JO - Ukrainian biochemical journal

JF - Ukrainian biochemical journal

SN - 2409-4943

IS - 1

ER -

ID: 42771409