Time course of the major enzymes (SDH, LDH, GPDHcyt, GPDHmit, AP) and protein synthesis (DNA, RNA) in spinal neurons and spinal ganglia after epidural injection of clofelin were studied in an acute experiment on dogs. No physiological or neurological disorders or depriming effect of clofelin on the major enzymatic systems and protein synthesis in nervous tissue of dogs were detected. Increased activity of AP in the spinal white and gray matter is worthy of note, which indicates intensification of active transport in spinal capillary epithelium after epidural injection of clofelin.