ACUTE BEHAVIORAL EFFECTS OF A NEW CHROMONE-CONTAINING ALLYLMORPHOLINE DERIVATIVE IN BALB/C MICE

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ACUTE BEHAVIORAL EFFECTS OF A NEW CHROMONE-CONTAINING ALLYLMORPHOLINE DERIVATIVE IN BALB/C MICE. / Puchik, Maria ; Shits, Darya ; Sysoev, Yuriy; Titovich, Irina; Okovityi, Sergey.

2024.

Research output: Working paper › Preprint

BibTeX

@techreport{1b00f70a1d374671b8792cf3fbda1b1d,

title = "ACUTE BEHAVIORAL EFFECTS OF A NEW CHROMONE-CONTAINING ALLYLMORPHOLINE DERIVATIVE IN BALB/C MICE",

abstract = "The effect of a chromone-containing allylmorpholine derivative in three dose ranges (1 mg/kg, 10 mg/kg and 50 mg/kg) on the behavior of BALB/C mice in the Elevated Plus Maze test was evaluated. A dose of 50 mg/kg induced a sedative effect in the tested animals, as evidenced by a decrease in the number of crossed squares, rearings and closed arms entries compared to the control group. The effects of dose of 10 mg/kg were similar to those of classical anxiolytic drugs (increased number of entries and total time in the open arms), but in all cases, there were no significant differences compared to the control. Thus, in the present work, the previously shown sedative effect of allylmorpholine 33a in zebrafish was confirmed. The probable anxiolytic activity of this compound requires further investigation.",

keywords = "allylmorpholines, elevated plus maze, BALB/C",

author = "Maria Puchik and Darya Shits and Yuriy Sysoev and Irina Titovich and Sergey Okovityi",

year = "2024",

language = "русский",

type = "WorkingPaper",

}

RIS

TY - UNPB

T1 - ACUTE BEHAVIORAL EFFECTS OF A NEW CHROMONE-CONTAINING ALLYLMORPHOLINE DERIVATIVE IN BALB/C MICE

AU - Puchik, Maria

AU - Shits, Darya

AU - Sysoev, Yuriy

AU - Titovich, Irina

AU - Okovityi, Sergey

PY - 2024

Y1 - 2024

N2 - The effect of a chromone-containing allylmorpholine derivative in three dose ranges (1 mg/kg, 10 mg/kg and 50 mg/kg) on the behavior of BALB/C mice in the Elevated Plus Maze test was evaluated. A dose of 50 mg/kg induced a sedative effect in the tested animals, as evidenced by a decrease in the number of crossed squares, rearings and closed arms entries compared to the control group. The effects of dose of 10 mg/kg were similar to those of classical anxiolytic drugs (increased number of entries and total time in the open arms), but in all cases, there were no significant differences compared to the control. Thus, in the present work, the previously shown sedative effect of allylmorpholine 33a in zebrafish was confirmed. The probable anxiolytic activity of this compound requires further investigation.

AB - The effect of a chromone-containing allylmorpholine derivative in three dose ranges (1 mg/kg, 10 mg/kg and 50 mg/kg) on the behavior of BALB/C mice in the Elevated Plus Maze test was evaluated. A dose of 50 mg/kg induced a sedative effect in the tested animals, as evidenced by a decrease in the number of crossed squares, rearings and closed arms entries compared to the control group. The effects of dose of 10 mg/kg were similar to those of classical anxiolytic drugs (increased number of entries and total time in the open arms), but in all cases, there were no significant differences compared to the control. Thus, in the present work, the previously shown sedative effect of allylmorpholine 33a in zebrafish was confirmed. The probable anxiolytic activity of this compound requires further investigation.

KW - allylmorpholines

KW - elevated plus maze

KW - BALB/C

M3 - Препринт

BT - ACUTE BEHAVIORAL EFFECTS OF A NEW CHROMONE-CONTAINING ALLYLMORPHOLINE DERIVATIVE IN BALB/C MICE

ER -

ID: 126517059