Standard

Activation of adenylyl cyclase by thienopyrimidine derivatives in rat testes and ovaries. / Shpakov, A.O.; Derkach, K.V.; Dar’in, D.V.; Lobanov, P.S.

In: Cell and Tissue Biology, No. 5, 2014, p. 400-406.

Research output: Contribution to journal › Article › peer-review

Harvard

Shpakov, AO, Derkach, KV, Dar’in, DV & Lobanov, PS 2014, 'Activation of adenylyl cyclase by thienopyrimidine derivatives in rat testes and ovaries', Cell and Tissue Biology, no. 5, pp. 400-406. https://doi.org/10.1134/S1990519X14050071

APA

Shpakov, A. O., Derkach, K. V., Dar’in, D. V., & Lobanov, P. S. (2014). Activation of adenylyl cyclase by thienopyrimidine derivatives in rat testes and ovaries. Cell and Tissue Biology, (5), 400-406. https://doi.org/10.1134/S1990519X14050071

Vancouver

Shpakov AO, Derkach KV, Dar’in DV, Lobanov PS. Activation of adenylyl cyclase by thienopyrimidine derivatives in rat testes and ovaries. Cell and Tissue Biology. 2014;(5):400-406. https://doi.org/10.1134/S1990519X14050071

Author

Shpakov, A.O. ; Derkach, K.V. ; Dar’in, D.V. ; Lobanov, P.S. / Activation of adenylyl cyclase by thienopyrimidine derivatives in rat testes and ovaries. In: Cell and Tissue Biology. 2014 ; No. 5. pp. 400-406.

BibTeX

@article{5775231c59b74da3bff99167f0016b2b,
title = "Activation of adenylyl cyclase by thienopyrimidine derivatives in rat testes and ovaries",
abstract = "{\textcopyright} 2014, Pleiades Publishing, Ltd. An important role in functioning of reproductive tissues is played by signaling systems that are regulated by luteinizing hormone (LH) and human chorionic gonadotropin (hCG) that include LH receptors as sensor components. Use of LH and hCG in medicine for treatment of diseases of the reproductive system and for solution of tasks of auxiliary reproductive technologies is restricted by their high cost, the necessity of parenteral introduction, and the presence of side effects. However, in the last few years, low molecular weight agonists of LH receptor have been developed that are devoid of these shortcomings and can be administered perorally. The most effective of them are thienopyrimidine derivatives, in particular the Org 43553 compound. The goal of this work was to study the effect of newly synthesized analogs of Org 43553, 5-amino-N-(tert-butyl)-4-(3-(isonicotinamide)phenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide (compound 1) and 5-amino-N-(tert-butyl)-2-(meth",
author = "A.O. Shpakov and K.V. Derkach and D.V. Dar{\textquoteright}in and P.S. Lobanov",
year = "2014",
doi = "10.1134/S1990519X14050071",
language = "English",
pages = "400--406",
journal = "Cell and Tissue Biology",
issn = "1990-519X",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "5",

}

RIS

TY - JOUR

T1 - Activation of adenylyl cyclase by thienopyrimidine derivatives in rat testes and ovaries

AU - Shpakov, A.O.

AU - Derkach, K.V.

AU - Dar’in, D.V.

AU - Lobanov, P.S.

PY - 2014

Y1 - 2014

N2 - © 2014, Pleiades Publishing, Ltd. An important role in functioning of reproductive tissues is played by signaling systems that are regulated by luteinizing hormone (LH) and human chorionic gonadotropin (hCG) that include LH receptors as sensor components. Use of LH and hCG in medicine for treatment of diseases of the reproductive system and for solution of tasks of auxiliary reproductive technologies is restricted by their high cost, the necessity of parenteral introduction, and the presence of side effects. However, in the last few years, low molecular weight agonists of LH receptor have been developed that are devoid of these shortcomings and can be administered perorally. The most effective of them are thienopyrimidine derivatives, in particular the Org 43553 compound. The goal of this work was to study the effect of newly synthesized analogs of Org 43553, 5-amino-N-(tert-butyl)-4-(3-(isonicotinamide)phenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide (compound 1) and 5-amino-N-(tert-butyl)-2-(meth

AB - © 2014, Pleiades Publishing, Ltd. An important role in functioning of reproductive tissues is played by signaling systems that are regulated by luteinizing hormone (LH) and human chorionic gonadotropin (hCG) that include LH receptors as sensor components. Use of LH and hCG in medicine for treatment of diseases of the reproductive system and for solution of tasks of auxiliary reproductive technologies is restricted by their high cost, the necessity of parenteral introduction, and the presence of side effects. However, in the last few years, low molecular weight agonists of LH receptor have been developed that are devoid of these shortcomings and can be administered perorally. The most effective of them are thienopyrimidine derivatives, in particular the Org 43553 compound. The goal of this work was to study the effect of newly synthesized analogs of Org 43553, 5-amino-N-(tert-butyl)-4-(3-(isonicotinamide)phenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide (compound 1) and 5-amino-N-(tert-butyl)-2-(meth

U2 - 10.1134/S1990519X14050071

DO - 10.1134/S1990519X14050071

M3 - Article

SP - 400

EP - 406

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - 5

ER -

ID: 7061385