DOI

A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)2-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported basepromoted unimolecular cyclization of propargylureas (leading to 2-imidazolones) and extend the range of Lewis acid-catalyzed azole syntheses based on N-carbonyl propargylamines.

Original languageEnglish
Pages (from-to)1061-1064
Number of pages4
JournalBeilstein Journal of Organic Chemistry
Volume15
DOIs
StatePublished - 1 Jan 2019

    Research areas

  • Alkyne hydroamination, Cyclocondensation, Lewis acid catalysis, Multicomponent reactions, Propargylurea

    Scopus subject areas

  • Organic Chemistry

ID: 42472727