A systematic review and meta-analysis of imaging genetics studies of specific reading disorder

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A systematic review and meta-analysis of imaging genetics studies of specific reading disorder. / Thomas, Tina; Khalaf, Shiva; Grigorenko, Elena L.

In: Cognitive Neuropsychology, Vol. 38, No. 3, 03.04.2021, p. 179-204.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{d593f71788cd436d83e9660b7d2af0fe,

title = "A systematic review and meta-analysis of imaging genetics studies of specific reading disorder",

abstract = "The imaging genetics of specific reading disabilities (SRD) is an emerging field that aims to characterize the disabilities{\textquoteright} neurobiological causes, including atypical brain structure and function and distinct genetic architecture. The present review aimed to summarize current imaging genetics studies of SRD, characterize the effect sizes of reported results by calculating Cohen{\textquoteright}s d, complete a Fisher{\textquoteright}s Combined Probability Test for genes featured in multiple studies, and determine areas for future research. Results demonstrate associations between SRD risk genes and reading network brain phenotypes. The Fisher{\textquoteright}s test revealed promising results for the genes DCDC2, KIAA0319, FOXP2, SLC2A3, and ROBO1. Future research should focus on exploratory approaches to identify previously undiscovered genes. Using comprehensive neuroimaging (e.g., functional and effective connectivity) and genetic (e.g., sequencing and epigenetic) techniques, and using larger samples, diverse stages of development, and longitudinal investigations, would help researchers understand the neurobiological correlates of SRD to improve early identification.",

keywords = "genetics, imaging, Imaging genetics, reading disability, Neuroimaging, Brain/diagnostic imaging, Dyslexia/genetics, Humans, Microtubule-Associated Proteins, Receptors, Immunologic, Nerve Tissue Proteins, LANGUAGE, RISK-FACTORS, VARIANTS, WHITE-MATTER, DCDC2, SUSCEPTIBILITY GENE, DEVELOPMENTAL DYSLEXIA, KIAA0319, ALTERED BRAIN ACTIVATION, GENOME-WIDE ASSOCIATION",

author = "Tina Thomas and Shiva Khalaf and Grigorenko, {Elena L.}",

note = "Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

month = apr,

day = "3",

doi = "10.1080/02643294.2021.1969900",

language = "English",

volume = "38",

pages = "179--204",

journal = "Cognitive Neuropsychology",

issn = "0264-3294",

publisher = "Taylor & Francis",

number = "3",

}

RIS

TY - JOUR

T1 - A systematic review and meta-analysis of imaging genetics studies of specific reading disorder

AU - Thomas, Tina

AU - Khalaf, Shiva

AU - Grigorenko, Elena L.

PY - 2021/4/3

Y1 - 2021/4/3

N2 - The imaging genetics of specific reading disabilities (SRD) is an emerging field that aims to characterize the disabilities’ neurobiological causes, including atypical brain structure and function and distinct genetic architecture. The present review aimed to summarize current imaging genetics studies of SRD, characterize the effect sizes of reported results by calculating Cohen’s d, complete a Fisher’s Combined Probability Test for genes featured in multiple studies, and determine areas for future research. Results demonstrate associations between SRD risk genes and reading network brain phenotypes. The Fisher’s test revealed promising results for the genes DCDC2, KIAA0319, FOXP2, SLC2A3, and ROBO1. Future research should focus on exploratory approaches to identify previously undiscovered genes. Using comprehensive neuroimaging (e.g., functional and effective connectivity) and genetic (e.g., sequencing and epigenetic) techniques, and using larger samples, diverse stages of development, and longitudinal investigations, would help researchers understand the neurobiological correlates of SRD to improve early identification.

AB - The imaging genetics of specific reading disabilities (SRD) is an emerging field that aims to characterize the disabilities’ neurobiological causes, including atypical brain structure and function and distinct genetic architecture. The present review aimed to summarize current imaging genetics studies of SRD, characterize the effect sizes of reported results by calculating Cohen’s d, complete a Fisher’s Combined Probability Test for genes featured in multiple studies, and determine areas for future research. Results demonstrate associations between SRD risk genes and reading network brain phenotypes. The Fisher’s test revealed promising results for the genes DCDC2, KIAA0319, FOXP2, SLC2A3, and ROBO1. Future research should focus on exploratory approaches to identify previously undiscovered genes. Using comprehensive neuroimaging (e.g., functional and effective connectivity) and genetic (e.g., sequencing and epigenetic) techniques, and using larger samples, diverse stages of development, and longitudinal investigations, would help researchers understand the neurobiological correlates of SRD to improve early identification.

KW - genetics

KW - imaging

KW - Imaging genetics

KW - reading disability

KW - Neuroimaging

KW - Brain/diagnostic imaging

KW - Dyslexia/genetics

KW - Humans

KW - Microtubule-Associated Proteins

KW - Receptors, Immunologic

KW - Nerve Tissue Proteins

KW - LANGUAGE

KW - RISK-FACTORS

KW - VARIANTS

KW - WHITE-MATTER

KW - DCDC2

KW - SUSCEPTIBILITY GENE

KW - DEVELOPMENTAL DYSLEXIA

KW - KIAA0319

KW - ALTERED BRAIN ACTIVATION

KW - GENOME-WIDE ASSOCIATION

UR - http://www.scopus.com/inward/record.url?scp=85115198159&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6a65030d-ac88-334c-8d42-0c500c8d4956/

U2 - 10.1080/02643294.2021.1969900

DO - 10.1080/02643294.2021.1969900

M3 - Review article

C2 - 34529546

AN - SCOPUS:85115198159

VL - 38

SP - 179

EP - 204

JO - Cognitive Neuropsychology

JF - Cognitive Neuropsychology

SN - 0264-3294

IS - 3

ER -

ID: 86655709