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A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis. / Dar'In, Dmitry; Kantin, Grigory; Krasavin, Mikhail.

In: Chemical Communications, Vol. 55, No. 36, 2019, p. 5239-5242.

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@article{6bc3877dec204e949366738f97222fed,
title = "A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis",
abstract = "Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations.",
keywords = "MULTIGRAM-SCALE SYNTHESIS",
author = "Dmitry Dar'In and Grigory Kantin and Mikhail Krasavin",
year = "2019",
doi = "10.1039/c9cc02042j",
language = "English",
volume = "55",
pages = "5239--5242",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "36",

}

RIS

TY - JOUR

T1 - A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis

AU - Dar'In, Dmitry

AU - Kantin, Grigory

AU - Krasavin, Mikhail

PY - 2019

Y1 - 2019

N2 - Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations.

AB - Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations.

KW - MULTIGRAM-SCALE SYNTHESIS

UR - http://www.scopus.com/inward/record.url?scp=85065103869&partnerID=8YFLogxK

U2 - 10.1039/c9cc02042j

DO - 10.1039/c9cc02042j

M3 - Article

C2 - 30985842

AN - SCOPUS:85065103869

VL - 55

SP - 5239

EP - 5242

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 36

ER -

ID: 49034684