Research output: Contribution to journal › Article › peer-review
A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis. / Dar'In, Dmitry; Kantin, Grigory; Krasavin, Mikhail.
In: Chemical Communications, Vol. 55, No. 36, 2019, p. 5239-5242.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis
AU - Dar'In, Dmitry
AU - Kantin, Grigory
AU - Krasavin, Mikhail
PY - 2019
Y1 - 2019
N2 - Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations.
AB - Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations.
KW - MULTIGRAM-SCALE SYNTHESIS
UR - http://www.scopus.com/inward/record.url?scp=85065103869&partnerID=8YFLogxK
U2 - 10.1039/c9cc02042j
DO - 10.1039/c9cc02042j
M3 - Article
C2 - 30985842
AN - SCOPUS:85065103869
VL - 55
SP - 5239
EP - 5242
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 36
ER -
ID: 49034684