TY - JOUR

T1 - A Private History of Neurogenetics

T2 - The swiss cheese Gene and Its Orthologs

AU - Melentev, P. A.

AU - Ryabova, E. V.

AU - Sarantseva, S. V.

N1 - Melentev, P.A., Ryabova, E.V. & Sarantseva, S.V. A Private History of Neurogenetics: The swiss cheese Gene and Its Orthologs. Russ J Genet 57, 1115–1130 (2021). https://doi.org/10.1134/S1022795421090076

PY - 2021/10

Y1 - 2021/10

N2 - Abstract: One of the problems in genetics concerns the role of heredity in behavioral traits of humans and animals. As was believed for many years, behavior is determined by both the environment and the pleiotropic effect of multiple genes, making discrete hereditary factors of behavior elusive. The purposeful production and study of behavior-altered mutants in Drosophila, which was started by Seymour Benzer more than half a century ago, laid the foundation for the direction called neurogenetics. Further establishment of a connection between mutations and various phenotypes made it possible to reveal the role of genes in the determination of functions of the nervous system and in the corresponding regulation of behavior. One of the numerous genes discovered by Seymour Benzer and his followers, in particular, Martin Heisenberg, in the course of research on Drosophila mutants was the swiss cheese gene, which regulates viability of neurons and glial cells. Multiple studies of this evolutionary conservative gene and its orthologs, prompted by interest in analysis of genetic control of viability of nervous tissue cells, decoding the biological mechanisms of the action of organophosphate poisons, and investigation of some hereditary human syndromes, made it possible to identify certain aspects of the role of the swiss cheese gene and its orthologs in cell metabolism, functioning of the nervous system, and regulation of behavior.

AB - Abstract: One of the problems in genetics concerns the role of heredity in behavioral traits of humans and animals. As was believed for many years, behavior is determined by both the environment and the pleiotropic effect of multiple genes, making discrete hereditary factors of behavior elusive. The purposeful production and study of behavior-altered mutants in Drosophila, which was started by Seymour Benzer more than half a century ago, laid the foundation for the direction called neurogenetics. Further establishment of a connection between mutations and various phenotypes made it possible to reveal the role of genes in the determination of functions of the nervous system and in the corresponding regulation of behavior. One of the numerous genes discovered by Seymour Benzer and his followers, in particular, Martin Heisenberg, in the course of research on Drosophila mutants was the swiss cheese gene, which regulates viability of neurons and glial cells. Multiple studies of this evolutionary conservative gene and its orthologs, prompted by interest in analysis of genetic control of viability of nervous tissue cells, decoding the biological mechanisms of the action of organophosphate poisons, and investigation of some hereditary human syndromes, made it possible to identify certain aspects of the role of the swiss cheese gene and its orthologs in cell metabolism, functioning of the nervous system, and regulation of behavior.

KW - neurodegeneration

KW - neurogenetics

KW - NTE

KW - PNPLA6

KW - Seymour Benzer

KW - swiss cheese

UR - http://www.scopus.com/inward/record.url?scp=85116899445&partnerID=8YFLogxK

U2 - 10.1134/S1022795421090076

DO - 10.1134/S1022795421090076

M3 - Article

AN - SCOPUS:85116899445

VL - 57

SP - 1115

EP - 1130

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 10

ER -