Research output: Contribution to journal › Article › peer-review
An alternative route from 1,3-disubstituted barbituric acids to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones was developed that features sulfonyl-azide-free (SAFE) diazo transfer and Rh2(esp)2-catalyzed cycloaddition of the resulting 5-diazobarbituric acids with aliphatic and aromatic nitriles. Besides being shorter compared to the previously described approaches, the method allows introduction of alkyl substituents at the 1,3-oxazole ring of the fused heterocyclic system.
Original language | English |
---|---|
Article number | 151120 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 60 |
Issue number | 44 |
Early online date | 6 Sep 2019 |
DOIs | |
State | Published - 31 Oct 2019 |
ID: 49034163