Standard

A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation. / Serebryanskaya, T.V.; Zolotarev, A.A.; Ott, I.

In: MedChemComm, Vol. 6, No. 6, 2015, p. 1186-1189.

Research output: Contribution to journal › Article

Harvard

Serebryanskaya, TV, Zolotarev, AA & Ott, I 2015, 'A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation', MedChemComm, vol. 6, no. 6, pp. 1186-1189. https://doi.org/10.1039/c5md00185d

APA

Serebryanskaya, T. V., Zolotarev, A. A., & Ott, I. (2015). A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation. MedChemComm, 6(6), 1186-1189. https://doi.org/10.1039/c5md00185d

Vancouver

Serebryanskaya TV, Zolotarev AA, Ott I. A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation. MedChemComm. 2015;6(6):1186-1189. https://doi.org/10.1039/c5md00185d

Author

Serebryanskaya, T.V. ; Zolotarev, A.A. ; Ott, I. / A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation. In: MedChemComm. 2015 ; Vol. 6, No. 6. pp. 1186-1189.

BibTeX

@article{393f1946f19c4b27bb4cfa7782410834,
title = "A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation",
abstract = "A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.",
keywords = "Gold(I) NHC complex, triazolium salt, anticancer activity, TrX inhibition, cellular uptake",
author = "T.V. Serebryanskaya and A.A. Zolotarev and I. Ott",
year = "2015",
doi = "10.1039/c5md00185d",
language = "English",
volume = "6",
pages = "1186--1189",
journal = "MedChemComm",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "6",

}

RIS

TY - JOUR

T1 - A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation

AU - Serebryanskaya, T.V.

AU - Zolotarev, A.A.

AU - Ott, I.

PY - 2015

Y1 - 2015

N2 - A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.

AB - A novel gold(I) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.

KW - Gold(I) NHC complex

KW - triazolium salt

KW - anticancer activity

KW - TrX inhibition

KW - cellular uptake

U2 - 10.1039/c5md00185d

DO - 10.1039/c5md00185d

M3 - Article

VL - 6

SP - 1186

EP - 1189

JO - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 6

ER -

ID: 3939164