A Low-Cost, Simple Method for Isotopic Analysis of Enriched Boron Pharmaceutical Substances by Capillary Zone Electrophoresis with Indirect UV Detection

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A Low-Cost, Simple Method for Isotopic Analysis of Enriched Boron Pharmaceutical Substances by Capillary Zone Electrophoresis with Indirect UV Detection. / Malinina, Yulia ; Yakimova, Nina ; Moskvin, Leonid ; Tkach, Kirill ; Kamentsev, Mikhail ; Kuchumova, Irina .

In: Chromatographia, Vol. 84, No. 4, 04.2021, p. 393-398.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{3d306f3b86e04321b6144e7bf3b9bc2e,

title = "A Low-Cost, Simple Method for Isotopic Analysis of Enriched Boron Pharmaceutical Substances by Capillary Zone Electrophoresis with Indirect UV Detection",

abstract = "A novel, cheap and simple method for the determination of 10B and 11B mole fractions in 10B enriched boron compounds by capillary zone electrophoresis with indirect UV detection was developed. The background electrolyte contained 35 mM phenylalanine adjusted to pH of 8.8 with putrescine. The running conditions were + 25 kV at 34° C. Indirect photometric detection was performed at 210 nm. The analysis time was less than 17 min. The interday RSD of migration times and peak areas were less than 0.9% and 2.3%, respectively (n = 18). Linearity was demonstrated in the range 0.3–15 mM for both isotopes. Analysis of boron compounds with mole fraction of 10B ranging from 19.8 (natural abundance) up to 90.0% was successfully demonstrated.",

keywords = "Isotopic Analysis,Boron Pharmaceutical Substances ,Capillary Zone Electrophoresis, Capillary electrophoresis, Capillary zone electrophoresis, Isotopic separation, Boron neutron capture, Boron isotope",

author = "Yulia Malinina and Nina Yakimova and Leonid Moskvin and Kirill Tkach and Mikhail Kamentsev and Irina Kuchumova",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.",

year = "2021",

month = apr,

doi = "10.1007/s10337-020-03995-9",

language = "English",

volume = "84",

pages = "393--398",

journal = "Chromatographia",

issn = "0009-5893",

publisher = "Springer Nature",

number = "4",

}

RIS

TY - JOUR

T1 - A Low-Cost, Simple Method for Isotopic Analysis of Enriched Boron Pharmaceutical Substances by Capillary Zone Electrophoresis with Indirect UV Detection

AU - Malinina, Yulia

AU - Yakimova, Nina

AU - Moskvin, Leonid

AU - Tkach, Kirill

AU - Kamentsev, Mikhail

AU - Kuchumova, Irina

PY - 2021/4

Y1 - 2021/4

N2 - A novel, cheap and simple method for the determination of 10B and 11B mole fractions in 10B enriched boron compounds by capillary zone electrophoresis with indirect UV detection was developed. The background electrolyte contained 35 mM phenylalanine adjusted to pH of 8.8 with putrescine. The running conditions were + 25 kV at 34° C. Indirect photometric detection was performed at 210 nm. The analysis time was less than 17 min. The interday RSD of migration times and peak areas were less than 0.9% and 2.3%, respectively (n = 18). Linearity was demonstrated in the range 0.3–15 mM for both isotopes. Analysis of boron compounds with mole fraction of 10B ranging from 19.8 (natural abundance) up to 90.0% was successfully demonstrated.

AB - A novel, cheap and simple method for the determination of 10B and 11B mole fractions in 10B enriched boron compounds by capillary zone electrophoresis with indirect UV detection was developed. The background electrolyte contained 35 mM phenylalanine adjusted to pH of 8.8 with putrescine. The running conditions were + 25 kV at 34° C. Indirect photometric detection was performed at 210 nm. The analysis time was less than 17 min. The interday RSD of migration times and peak areas were less than 0.9% and 2.3%, respectively (n = 18). Linearity was demonstrated in the range 0.3–15 mM for both isotopes. Analysis of boron compounds with mole fraction of 10B ranging from 19.8 (natural abundance) up to 90.0% was successfully demonstrated.

KW - Isotopic Analysis,Boron Pharmaceutical Substances ,Capillary Zone Electrophoresis

KW - Capillary electrophoresis

KW - Capillary zone electrophoresis

KW - Isotopic separation

KW - Boron neutron capture

KW - Boron isotope

UR - https://link.springer.com/article/10.1007/s10337-020-03995-9

UR - http://www.scopus.com/inward/record.url?scp=85101036614&partnerID=8YFLogxK

U2 - 10.1007/s10337-020-03995-9

DO - 10.1007/s10337-020-03995-9

M3 - Article

VL - 84

SP - 393

EP - 398

JO - Chromatographia

JF - Chromatographia

SN - 0009-5893

IS - 4

ER -

ID: 87278175