Research output: Contribution to journal › Article › peer-review
A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans. / Podar, Mircea; Anderson, Iain; Makarova, Kira S.; Elkins, James G.; Wall, Mark A.; Lykidis, Athanasios; Mavromatis, Kostantinos; Sun, Hui; Hudson, Matthew E.; Chen, Wenqiong; Deciu, Cosmin; Hutchison, Don; Eads, Jonathan R.; Anderson, Abraham; Fernandes, Fillipe; Szeto, Ernest; Lapidus, Alla; Kyrpides, Nikos C.; Saier, Milton H.; Richardson, Paul M.; Rachel, Reinhard; Huber, Harald; Eisen, Jonathan A.; Koonin, Eugene V.; Keller, Martin; Stetter, Karl O.
In: Genome Biology, Vol. 9, No. 11, R158, 10.11.2008.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans
AU - Podar, Mircea
AU - Anderson, Iain
AU - Makarova, Kira S.
AU - Elkins, James G.
AU - Wall, Mark A.
AU - Lykidis, Athanasios
AU - Mavromatis, Kostantinos
AU - Sun, Hui
AU - Hudson, Matthew E.
AU - Chen, Wenqiong
AU - Deciu, Cosmin
AU - Hutchison, Don
AU - Eads, Jonathan R.
AU - Anderson, Abraham
AU - Fernandes, Fillipe
AU - Szeto, Ernest
AU - Lapidus, Alla
AU - Kyrpides, Nikos C.
AU - Saier, Milton H.
AU - Richardson, Paul M.
AU - Rachel, Reinhard
AU - Huber, Harald
AU - Eisen, Jonathan A.
AU - Koonin, Eugene V.
AU - Keller, Martin
AU - Stetter, Karl O.
N1 - Funding Information: We thank Diversa/Verenium Corporation (San Diego, CA), JGI production sequencing group and the Computational Biology Group at Oak Ridge National Laboratory (Oak Ridge, TN) for sequencing and annotation support. MP, JGE and MK were supported by the US Department of Energy, Office of Science, Biological and Environmental Research programs at Oak Ridge National Laboratory (ORNL). ORNL is managed by UT-Battelle, LLC, for the US Department of Energy under contract DE-AC05-00OR22725. Support for sequencing and data analysis was provided by the Joint Genome Institute, the US Department of Energy (IA, NI, AL, KM, HS, ES, AL, NK and PR). Diversa Corporation provided support for MP, MW, WC, CD, DH, JRE, AA and FF. KSM and EVK are supported by the Intramural Research Program of the National Institutes of Health, National Library of Medicine. HH, RR and KOS were supported by grants from the Deutsche Forschungsgemeinschaft.
PY - 2008/11/10
Y1 - 2008/11/10
N2 - Background: The relationship between the hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans is the only known example of a specific association between two species of Archaea. Little is known about the mechanisms that enable this relationship. Results: We sequenced the complete genome of I. hospitalis and found it to be the smallest among independent, free-living organisms. A comparative genomic reconstruction suggests that the I. hospitalis lineage has lost most of the genes associated with a heterotrophic metabolism that is characteristic of most of the Crenarchaeota. A streamlined genome is also suggested by a low frequency of paralogs and fragmentation of many operons. However, this process appears to be partially balanced by lateral gene transfer from archaeal and bacterial sources. Conclusions: A combination of genomic and cellular features suggests highly efficient adaptation to the low energy yield of sulfur-hydrogen respiration and efficient inorganic carbon and nitrogen assimilation. Evidence of lateral gene exchange between N. equitans and I. hospitalis indicates that the relationship has impacted both genomes. This association is the simplest symbiotic system known to date and a unique model for studying mechanisms of interspecific relationships at the genomic and metabolic levels.
AB - Background: The relationship between the hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans is the only known example of a specific association between two species of Archaea. Little is known about the mechanisms that enable this relationship. Results: We sequenced the complete genome of I. hospitalis and found it to be the smallest among independent, free-living organisms. A comparative genomic reconstruction suggests that the I. hospitalis lineage has lost most of the genes associated with a heterotrophic metabolism that is characteristic of most of the Crenarchaeota. A streamlined genome is also suggested by a low frequency of paralogs and fragmentation of many operons. However, this process appears to be partially balanced by lateral gene transfer from archaeal and bacterial sources. Conclusions: A combination of genomic and cellular features suggests highly efficient adaptation to the low energy yield of sulfur-hydrogen respiration and efficient inorganic carbon and nitrogen assimilation. Evidence of lateral gene exchange between N. equitans and I. hospitalis indicates that the relationship has impacted both genomes. This association is the simplest symbiotic system known to date and a unique model for studying mechanisms of interspecific relationships at the genomic and metabolic levels.
UR - http://www.scopus.com/inward/record.url?scp=57049130376&partnerID=8YFLogxK
U2 - 10.1186/gb-2008-9-11-r158
DO - 10.1186/gb-2008-9-11-r158
M3 - Article
C2 - 19000309
AN - SCOPUS:57049130376
VL - 9
JO - Genome Biology
JF - Genome Biology
SN - 1474-7596
IS - 11
M1 - R158
ER -
ID: 90034534