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A Diastereoselective Route to Benzoannelated Bridged Sultams. / Соколов, Виктор Владимирович; Рассадин, Валентин Анатольевич; Клочкова, Анастасия Андреевна.

In: Synthesis, Vol. 53, No. 23, 01.12.2021, p. 4484-4494.

Research output: Contribution to journal › Article › peer-review

Harvard

Соколов, ВВ, Рассадин, ВА & Клочкова, АА 2021, 'A Diastereoselective Route to Benzoannelated Bridged Sultams', Synthesis, vol. 53, no. 23, pp. 4484-4494. https://doi.org/10.1055/a-1531-2176

APA

Соколов, В. В., Рассадин, В. А., & Клочкова, А. А. (2021). A Diastereoselective Route to Benzoannelated Bridged Sultams. Synthesis, 53(23), 4484-4494. https://doi.org/10.1055/a-1531-2176

Vancouver

Соколов ВВ, Рассадин ВА, Клочкова АА. A Diastereoselective Route to Benzoannelated Bridged Sultams. Synthesis. 2021 Dec 1;53(23):4484-4494. https://doi.org/10.1055/a-1531-2176

Author

Соколов, Виктор Владимирович ; Рассадин, Валентин Анатольевич ; Клочкова, Анастасия Андреевна. / A Diastereoselective Route to Benzoannelated Bridged Sultams. In: Synthesis. 2021 ; Vol. 53, No. 23. pp. 4484-4494.

BibTeX

@article{6c4ab1803780481ba05dcb50279051c5,
title = "A Diastereoselective Route to Benzoannelated Bridged Sultams",
abstract = "A practical diastereoselective method for the synthesis of benzoannelated tri- and tetracyclic bridged sultams has been developed. The synthetic route employs widely available, substituted -iodoanilines and is based on intramolecular Michael addition followed by cycloalkylation with dihaloalkanes, or vice versa. The target compounds were isolated in good yields and the diastereoselectivity of the reaction could be easily controlled by the order of Michael addition and cycloalkylation steps.",
keywords = "Michael addition, bridged sultams, cycloalkylation, diastereoselective synthesis, heterocycles, ANNULATION, CAMPHOR, SULFONAMIDES, SULFUR, ACCESS",
author = "Соколов, {Виктор Владимирович} and Рассадин, {Валентин Анатольевич} and Клочкова, {Анастасия Андреевна}",
year = "2021",
month = dec,
day = "1",
doi = "10.1055/a-1531-2176",
language = "English",
volume = "53",
pages = "4484--4494",
journal = "Synthesis",
issn = "0039-7881",
publisher = "Georg Thieme Verlag",
number = "23",

}

RIS

TY - JOUR

T1 - A Diastereoselective Route to Benzoannelated Bridged Sultams

AU - Соколов, Виктор Владимирович

AU - Рассадин, Валентин Анатольевич

AU - Клочкова, Анастасия Андреевна

PY - 2021/12/1

Y1 - 2021/12/1

N2 - A practical diastereoselective method for the synthesis of benzoannelated tri- and tetracyclic bridged sultams has been developed. The synthetic route employs widely available, substituted -iodoanilines and is based on intramolecular Michael addition followed by cycloalkylation with dihaloalkanes, or vice versa. The target compounds were isolated in good yields and the diastereoselectivity of the reaction could be easily controlled by the order of Michael addition and cycloalkylation steps.

AB - A practical diastereoselective method for the synthesis of benzoannelated tri- and tetracyclic bridged sultams has been developed. The synthetic route employs widely available, substituted -iodoanilines and is based on intramolecular Michael addition followed by cycloalkylation with dihaloalkanes, or vice versa. The target compounds were isolated in good yields and the diastereoselectivity of the reaction could be easily controlled by the order of Michael addition and cycloalkylation steps.

KW - Michael addition

KW - bridged sultams

KW - cycloalkylation

KW - diastereoselective synthesis

KW - heterocycles

KW - ANNULATION

KW - CAMPHOR

KW - SULFONAMIDES

KW - SULFUR

KW - ACCESS

UR - http://www.scopus.com/inward/record.url?scp=85112210100&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/349d4ae3-4c1e-381d-a639-2812b4665885/

U2 - 10.1055/a-1531-2176

DO - 10.1055/a-1531-2176

M3 - Article

VL - 53

SP - 4484

EP - 4494

JO - Synthesis

JF - Synthesis

SN - 0039-7881

IS - 23

ER -

ID: 88047966