TY - JOUR

T1 - A Comparative Study of the Plasma Chemokine Profile in COVID-19 Patients Infected with Different SARS-CoV-2 Variants

AU - Korobova, Zoia R.

AU - Arsentieva, Natalia A.

AU - Liubimova, Natalia E.

AU - Dedkov, Vladimir G.

AU - Gladkikh, Anna S.

AU - Sharova, Alena A.

AU - Chernykh, Ekaterina I.

AU - Kashchenko, Victor A.

AU - Ratnikov, Vyacheslav A.

AU - Gorelov, Victor P.

AU - Stanevich, Oksana V.

AU - Kulikov, Alexandr N.

AU - Pevtsov, Dmitriy E.

AU - Totolian, Areg A.

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022/8/13

Y1 - 2022/8/13

N2 - Background. Infection caused by SARS-CoV-2 mostly affects the upper and lower respiratory tracts and causes symptoms ranging from the common cold to pneumonia with acute respiratory distress syndrome. Chemokines are deeply involved in the chemoattraction, proliferation, and activation of immune cells within inflammation. It is crucial to consider that mutations within the virion can potentially affect the clinical course of SARS-CoV-2 infection because disease severity and manifestation vary depending on the genetic variant. Our objective was to measure and assess the different concentrations of chemokines involved in COVID-19 caused by different variants of the virus. Methods. We used the blood plasma of patients infected with different variants of SARS-CoV-2, i.e., the ancestral Wuhan strain and the Alpha, Delta, and Omicron variants. We measured the concentrations of 11 chemokines in the samples: CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL7/MCP-3, CCL11/Eotaxin, CCL22/MDC, CXCL1/GROα, CXCL8/IL-8, CXCL9/MIG, CXCL10/IP-10, and CX3CL1/Fractalkine. Results. We noted a statistically significant elevation in the concentrations of CCL2/MCP-1, CXCL8/IL-8, and CXCL1/IP-10 independently of the variant, and a drop in the CCL22/MDC concentrations. Conclusions. The chemokine concentrations varied significantly depending on the viral variant, leading us to infer that mutations in viral proteins play a role in the cellular and molecular mechanisms of immune responses.

AB - Background. Infection caused by SARS-CoV-2 mostly affects the upper and lower respiratory tracts and causes symptoms ranging from the common cold to pneumonia with acute respiratory distress syndrome. Chemokines are deeply involved in the chemoattraction, proliferation, and activation of immune cells within inflammation. It is crucial to consider that mutations within the virion can potentially affect the clinical course of SARS-CoV-2 infection because disease severity and manifestation vary depending on the genetic variant. Our objective was to measure and assess the different concentrations of chemokines involved in COVID-19 caused by different variants of the virus. Methods. We used the blood plasma of patients infected with different variants of SARS-CoV-2, i.e., the ancestral Wuhan strain and the Alpha, Delta, and Omicron variants. We measured the concentrations of 11 chemokines in the samples: CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL7/MCP-3, CCL11/Eotaxin, CCL22/MDC, CXCL1/GROα, CXCL8/IL-8, CXCL9/MIG, CXCL10/IP-10, and CX3CL1/Fractalkine. Results. We noted a statistically significant elevation in the concentrations of CCL2/MCP-1, CXCL8/IL-8, and CXCL1/IP-10 independently of the variant, and a drop in the CCL22/MDC concentrations. Conclusions. The chemokine concentrations varied significantly depending on the viral variant, leading us to infer that mutations in viral proteins play a role in the cellular and molecular mechanisms of immune responses.

KW - chemokines

KW - COVID-19

KW - macrophage-derived chemokine

KW - Omicron

KW - SARS-CoV-2 variants

KW - Plasma

KW - SARS-CoV-2

KW - Humans

KW - COVID-19/immunology

KW - Chemokines/blood

KW - Interleukin-8

KW - Chemokine CXCL10

UR - http://www.scopus.com/inward/record.url?scp=85136714937&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/10de4cb0-c4c3-3064-a849-e69a900663b6/

U2 - 10.3390/ijms23169058

DO - 10.3390/ijms23169058

M3 - Article

C2 - 36012323

AN - SCOPUS:85136714937

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 16

M1 - 9058

ER -