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A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior. / Beaulieu, Jean Martin; Marion, Sébastien; Rodriguiz, Ramona M.; Medvedev, Ivan O.; Sotnikova, Tatyana D.; Ghisi, Valentina; Wetsel, William C.; Lefkowitz, Robert J.; Gainetdinov, Raul R.; Caron, Marc G.

In: Cell, Vol. 132, No. 1, 11.01.2008, p. 125-136.

Research output: Contribution to journal › Article › peer-review

Harvard

Beaulieu, JM, Marion, S, Rodriguiz, RM, Medvedev, IO, Sotnikova, TD, Ghisi, V, Wetsel, WC, Lefkowitz, RJ, Gainetdinov, RR & Caron, MG 2008, 'A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior', Cell, vol. 132, no. 1, pp. 125-136. https://doi.org/10.1016/j.cell.2007.11.041

APA

Beaulieu, J. M., Marion, S., Rodriguiz, R. M., Medvedev, I. O., Sotnikova, T. D., Ghisi, V., Wetsel, W. C., Lefkowitz, R. J., Gainetdinov, R. R., & Caron, M. G. (2008). A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior. Cell, 132(1), 125-136. https://doi.org/10.1016/j.cell.2007.11.041

Vancouver

Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V et al. A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior. Cell. 2008 Jan 11;132(1):125-136. https://doi.org/10.1016/j.cell.2007.11.041

Author

Beaulieu, Jean Martin ; Marion, Sébastien ; Rodriguiz, Ramona M. ; Medvedev, Ivan O. ; Sotnikova, Tatyana D. ; Ghisi, Valentina ; Wetsel, William C. ; Lefkowitz, Robert J. ; Gainetdinov, Raul R. ; Caron, Marc G. / A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior. In: Cell. 2008 ; Vol. 132, No. 1. pp. 125-136.

BibTeX

@article{0f55ea23542e4648af7ed53d6feedf3c,
title = "A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior",
abstract = "Besides their role in desensitization, β-arrestin 1 and 2 promote the formation of signaling complexes allowing G protein-coupled receptors (GPCR) to signal independently from G proteins. Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, β-arrestin 2, and protein phosphatase 2A. When administered to β-arrestin 2 knockout mice, lithium fails to affect Akt/GSK3 signaling and induce behavioral changes associated with GSK3 inhibition as it does in normal animals. These results point toward a pharmacological approach to modulating GPCR function that affects the formation of β-arrestin-mediated signaling complexes.",
keywords = "MOLNEURO",
author = "Beaulieu, {Jean Martin} and S{\'e}bastien Marion and Rodriguiz, {Ramona M.} and Medvedev, {Ivan O.} and Sotnikova, {Tatyana D.} and Valentina Ghisi and Wetsel, {William C.} and Lefkowitz, {Robert J.} and Gainetdinov, {Raul R.} and Caron, {Marc G.}",
year = "2008",
month = jan,
day = "11",
doi = "10.1016/j.cell.2007.11.041",
language = "English",
volume = "132",
pages = "125--136",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

AU - Beaulieu, Jean Martin

AU - Marion, Sébastien

AU - Rodriguiz, Ramona M.

AU - Medvedev, Ivan O.

AU - Sotnikova, Tatyana D.

AU - Ghisi, Valentina

AU - Wetsel, William C.

AU - Lefkowitz, Robert J.

AU - Gainetdinov, Raul R.

AU - Caron, Marc G.

PY - 2008/1/11

Y1 - 2008/1/11

N2 - Besides their role in desensitization, β-arrestin 1 and 2 promote the formation of signaling complexes allowing G protein-coupled receptors (GPCR) to signal independently from G proteins. Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, β-arrestin 2, and protein phosphatase 2A. When administered to β-arrestin 2 knockout mice, lithium fails to affect Akt/GSK3 signaling and induce behavioral changes associated with GSK3 inhibition as it does in normal animals. These results point toward a pharmacological approach to modulating GPCR function that affects the formation of β-arrestin-mediated signaling complexes.

AB - Besides their role in desensitization, β-arrestin 1 and 2 promote the formation of signaling complexes allowing G protein-coupled receptors (GPCR) to signal independently from G proteins. Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, β-arrestin 2, and protein phosphatase 2A. When administered to β-arrestin 2 knockout mice, lithium fails to affect Akt/GSK3 signaling and induce behavioral changes associated with GSK3 inhibition as it does in normal animals. These results point toward a pharmacological approach to modulating GPCR function that affects the formation of β-arrestin-mediated signaling complexes.

KW - MOLNEURO

UR - http://www.scopus.com/inward/record.url?scp=37649023273&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2007.11.041

DO - 10.1016/j.cell.2007.11.041

M3 - Article

C2 - 18191226

AN - SCOPUS:37649023273

VL - 132

SP - 125

EP - 136

JO - Cell

JF - Cell

SN - 0092-8674

IS - 1

ER -

ID: 36313310